Nonsteroidal Tissue Selective Androgen Receptor Modulators: A Promising Class of Clinical Candidates

    Michael L. Mohler, Vipin A. Nair, Dong-Jin Hwang, Igor M. Rakov, Renukadevi Patil, Duane D. Miller
    TLDR Selective androgen receptor modulators (SARMs) are a promising type of drug for various health conditions due to their targeted actions.
    The document discussed nonsteroidal tissue-selective androgen receptor modulators (SARMs) as a promising class of clinical candidates. These SARMs were highlighted for their potential to provide the beneficial effects of androgens, such as muscle growth and bone density improvement, without the undesirable side effects typically associated with steroidal androgens. The research emphasized the importance of tissue selectivity in minimizing adverse effects and maximizing therapeutic benefits, making SARMs a significant focus for future clinical applications.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 49 results

      community Binding affinity of pyrilutamide!

      in Update  167 upvotes 2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Topical finasteride now the safest possible path?

      in Finasteride/Dutasteride  82 upvotes 5 months ago
      Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 9 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community Ru58841 ruined my life. Here’s why.

      in Product  128 upvotes 2 years ago
      User experienced shortness of breath, high blood pressure, red eyes, and eye floaters after using RU58841 for hair loss. They warn others to avoid RU58841 and stick to finasteride, minoxidil, and dutasteride.

      community I am having Success with RU58841 and 1mm Derma Roller

      in Microneedling  19 upvotes 2 years ago
      A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

    Similar Research

    5 / 1000+ results