Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, the researchers reported that chloramphenicol-loaded liposomes, particularly those incorporating deoxycholic acid, enhanced follicular uptake and showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus, offering potential for treating MRSA-infected skin conditions with good skin biocompatibility and minimal toxicity.

This study found that minicircle-based gene therapy significantly lowered total homocysteine levels and improved liver CBS activity in a mouse model of CBS deficiency.

This study observed that a combination of low-dose cyclophosphamide and vinorelbine appears safe and has promising antitumor activity in patients with metastatic breast cancer resistant to anthracyclines and taxanes, achieving a 44% objective response rate at 6 months with manageable toxicity levels.

In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.

Treatment with oral terbinafine and topical enilconazole was successful in resolving a Trichophyton dermatophytosis outbreak in L'Hoest's monkeys, with complete mycological cure achieved after eight weeks.

This case report describes the effective treatment of psoroptic mange in Large White Yorkshire piglets using ivermectin, cefpodoxime, chlorpheniramine, povidone iodine, and Ascabiol lotion, resulting in full recovery and absence of mites.

This study found 100% efficacy in treating psoroptosis in sheep and wild goats using macrolide injections "Iveron-10" and "Dectomax," complemented by "Butox-50" bathing in sheep, though infestation initially affected all animals with varied severity.

This study found a high prevalence of parasitic infections in cattle in the Mymensingh district of Bangladesh, with mixed infections being more common and highlighting the need for improved management practices.

This study observed mycobacterial infection with M. xenopi in a pet ferret, noting its resistance to doxycycline, and highlighted the potential zoonotic transmission risk associated with such infections.

In this study, bezafibrate treatment improved certain aging-like features in a mouse model with mitochondrial dysfunction, but did not enhance muscle function or lifespan.

This study found that olorofim demonstrated potent in vitro and in vivo antifungal activity against dermatophytes, resolving skin lesions in a guinea pig model similar to clotrimazole, suggesting it may be a promising treatment for dermatophytosis.

This study found that topical Ivermectin 0.1% was the most effective treatment for rabbit mange among the tested options, achieving 100% survival, no persistent skin scales, and significant body weight changes, while topical cebacil gel resulted in 100% mortality and should not be used.

This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.

This study found that topical treatment with Maneb led to delayed epithelial cell degeneration in hair follicles of rats due to apoptosis.

In this study, researchers isolated five new compounds from Monascus purpureus wmd2424 and found that four exhibited mild antifungal activity against several fungi.

This study found that methotrexate treatment for 15 days suppressed tuberculin hypersensitivity in Strain 2 guinea pigs without causing lymphopenic or anti-inflammatory effects.

This review found that bimatoprost effectively treats chemotherapy-induced eyelash loss, known as milphosis, in cancer patients, as demonstrated in three small trials, but further research is needed due to limitations like small sample sizes and short follow-up periods.

In this study, Lactobacillus reuteri and Bacillus natto were found to potentially replace Aureomycin in alleviating weaning stress in piglets, based on growth, diarrhea rate, immunity, and other health indicators.

This study found that topical application of recombinant human MG53 protein mitigated nitrogen mustard-induced skin injuries in mice by preserving epidermal integrity and hair follicle structure.

This study reported that a novel nanomedicine combining berberine and sinapic acid significantly inhibited the growth of mouse mammary carcinoma cells and demonstrated an anti-tumor effect in vivo, without significant systemic toxicity after 28 days, suggesting a promising, low-toxicity therapeutic strategy for breast cancer.

This case report highlights that equine multisystemic eosinophilic epitheliotropic disease should be considered in horses presenting with skin lesions and gastrointestinal symptoms, as illustrated by the progression in a 5-year-old horse despite treatment.

This study observed that a 24-hour pre-treatment with MitoQ significantly protected H9c2 myoblasts from doxorubicin-induced damage while enhancing doxorubicin's effectiveness in prostate cancer cells, outperforming dexrazoxane's effects without compromising the anti-cancer efficacy.

This study reported successful treatment of sarcoptic mange in two wild bare-nosed wombats using three topical doses of moxidectin, clearing skin crusting and mites within two weeks.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

In this case report, a 2.5-year-old cat with scabies and bacterial pneumonia showed significant improvement in symptoms and hair regrowth following a treatment regimen including ivermectin, amoxicillin with clavulanic acid, diphenhydramine, methylprednisolone, and supportive therapies over 100 days.

This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.

The BAYONET trial is a phase II study designed to assess the efficacy and safety of combining encorafenib, binimetinib, and cetuximab for patients with BRAF V600E-mutant metastatic colorectal cancer that is resistant to encorafenib plus cetuximab; results are not yet reported.

This study found that three weekly injections of long-acting tetracycline effectively treated generalized bovine dermatophilosis in a buffalo dairy farm.

This study found that vismodegib was effective in treating basal cell carcinoma, achieving complete remission in some patients; however, significant side effects often required careful management to prevent therapy suspension, which can lead to resistance.

This study documented a case of Dipylidium caninum infection in a 4-month-old female dog, effectively treated with a deworming medication, resulting in significant improvement and no worms detected after five days. Routine deworming and maintaining hygienic conditions are recommended to prevent reinfection and transmission.