November 2025 in “Revista Políticas Públicas & Cidades” In this case study, the combination of microneedling and intradermal therapy was observed to effectively stimulate hair growth and improve hair density in a menopausal woman with androgenetic alopecia, resulting in enhanced self-esteem and cosmetic satisfaction.
This study developed a personalized microneedle that delivers finasteride directly to the skin, facilitating a sustained release and potentially reducing side effects associated with oral administration.
33 citations
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December 2017 in “Saudi Journal of Biological Sciences” In this study, researchers found that microRNAs in the oar-let-7 and oar-miR-200 families were significantly up-regulated during critical fetal periods of cashmere goat hair follicle development, suggesting their role in this process.
February 2026 in “Journal of drug targeting” This study found that combining laser ablation with nanoparticulate drug formulations effectively enhanced the skin and follicular delivery of hydrophilic drugs like minoxidil and minocycline in preclinical models.
3 citations
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June 2021 in “Actas Dermo-Sifiliográficas” This study found that dermoscopy can identify typical features of Malassezia folliculitis, such as folliculocentricity and perilesional erythema, offering a valuable tool for diagnosing this condition in clinical settings.
15 citations
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April 2021 in “International Journal of Pharmaceutics” This study found that smaller mesoporous silica particles (400-600 nm) accumulated in skin furrows, suggesting their potential as carriers for enhancing the delivery of topical medications like metronidazole.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that DHT may reduce the inflammatory responses induced by C. acnes in androgen-sensitive human sebocyte cells, suggesting a potential link between androgens and infection in sebaceous disorders.
5 citations
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August 2021 in “Experimental dermatology” This study suggests that Merkel cell polyomavirus T antigen-positive cells resembling Merkel cell carcinoma may originate from epithelial cells in human hair follicles, potentially informing future transgenic mouse models for this cancer.
July 2026 in “Materials Today Bio” This study demonstrated that in a mouse melanoma wound model, the MQ Microneedles effectively managed ROS levels to inhibit tumor growth and promote wound healing through light-controlled release.
23 citations
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March 2021 in “Gels” This study found that minoxidil solubilized in gelatin-containing microemulsions resulted in over 5% of the drug remaining in porcine skin, significantly more than the reference gel.
11 citations
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June 1974 in “Journal of Cutaneous Pathology” In this study, electron microscopy of follicular mucinosis showed severe cytoplasmic degeneration in hair follicles, with myelin figures and onion-like lamellar structures, but no indications of mucin release through degeneration or degradation were found.
May 2025 in “Lasers in Surgery and Medicine” This study reported that nonablative monopolar radiofrequency therapy provided sustained reductions in both inflammatory and noninflammatory acne lesion counts and sebum production in participants with moderate-to-severe acne vulgaris, with high patient satisfaction and no significant adverse effects observed up to 12 months posttreatment.
In this study, pilomatricoma, a benign skin tumor from hair follicle matrix cells, is highlighted as an important consideration when diagnosing painless, firm subcutaneous nodules, with accurate diagnosis relying on histopathological examination.
January 2024 in “Journal of Microorganism Control” In this study, researchers found that an antibacterial toner can penetrate keratin and sebum plugs and exhibits bactericidal effects against Cutibacterium acnes, as evidenced by a decrease in viable cell counts within artificial plugs inoculated with the bacteria.
This case report describes the first instance of basal cell carcinoma developing at the site of repeated microneedling for androgenetic alopecia, highlighting the need for further safety studies.
59 citations
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October 2016 in “Clinics in dermatology” This review discusses various sampling methods for studying Propionibacterium acnes in skin follicles and reports no new experimental results; the authors evaluate these methods' strengths and limitations.
1 citations
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February 2020 in “The Journal of clinical investigation/The journal of clinical investigation” This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.
62 citations
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September 2014 in “PLoS ONE” This study identified distinct human and bacterial protein profiles in sebaceous follicular casts, with acne samples showing proteins linked to inflammation and normal samples showing proteins involved in stress protection.
1 citations
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January 2022 in “Clinical dermatology review” This case report describes a 26-year-old male patient with trichofolliculoma, highlighting dermoscopic features that aid its diagnosis and distinct characteristics from other similar lesions.
20 citations
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June 1964 in “Archives of Dermatology” This study described three cases of follicular mucinosis and observed that one case responded rapidly to systemic corticosteroids, suggesting a potential therapeutic effect.
January 2025 in “Journal of Aesthetic Nursing” This review discusses the expanding role of microneedling in dermatology, highlighting its enhanced effectiveness when combined with other treatments like minoxidil, platelet-rich plasma, and exosomes, but reports no clinical results.
47 citations
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March 1987 in “The Journal of dermatologic surgery and oncology” Carbon dioxide laser treatment effectively removed facial hair cysts without scarring or them coming back.
August 2023 in “International Medical Case Reports Journal” In this case report, two patients with acne necrotica, one in early and one in late stages, showed improvement after treatment with topical mometasone furoate cream and doxycycline tablets, highlighting the under-recognition of this skin condition.
June 2025 in “Australasian Journal of Dermatology” This study introduced and evaluated a new dermoscopic feature, pigmented rings with central clearing, for improving the diagnosis of melasma and differentiating it from similar conditions.
May 2026 in “Journal of the American Academy of Dermatology” This study investigated the effectiveness of combining microneedling with 2% topical minoxidil in women with mild-to-moderate androgenetic alopecia and found that adding microneedling every 2 or 4 weeks did not enhance outcomes compared to using minoxidil alone over 24 weeks.
16 citations
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November 2020 in “In Vitro Cellular & Developmental Biology - Animal” This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.
1 citations
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January 2000 in “Journal of pharmacopuncture” This study confirmed that microneedle therapy systems (MTS) significantly improve hair growth and skin conditions, including acne and acne scars, without serious side effects.
June 2026 in “Drug Delivery and Translational Research” This study developed a spring-driven microneedle booster that improved early and cumulative delivery of minoxidil, accelerating hair regrowth compared to traditional roller methods in an androgenetic alopecia model.
February 2023 in “Ästhetische Dermatologie & Kosmetologie”
This study developed a co-design framework using finite element analysis to optimize bubble microneedles, achieving controlled tip separation and effective drug delivery through the skin and mucosa while maintaining insertion strength.