This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
December 2025 in “Mendeley Data” This article outlines a randomized trial to evaluate whether preoperative botulinum toxin administration can improve hair transplantation outcomes by reducing ischemia-induced graft failure.
4 citations
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August 2022 in “Aesthetic Surgery Journal” This study found that one session of intradermal botulinum toxin type A injection decreased scalp sebum secretion and perception of greasiness more effectively than saline for up to 3 months.
January 2018 in “프로그램북(구 초록집)” In this study, intradermal injection of botulinum toxin type A significantly increased hair count and improved physician-assessed hair condition in men with male pattern baldness after 24 weeks, with no serious adverse events reported beyond temporary local pain and redness.
January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, botulinum toxin type A did not improve clinical features in patients with recalcitrant alopecia totalis or alopecia universalis over a four-month period.
January 2021 in “Figshare” This review reports favorable outcomes for botulinum toxin injections in androgenic alopecia treatment, but findings are limited by small sample sizes and lack of control groups.
24 citations
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January 2017 in “Journal of Cutaneous and Aesthetic Surgery” In this pilot study, botulinum toxin was found to be a safe and effective treatment for androgenetic alopecia in most participants, though larger studies are needed to confirm these findings.
October 2025 in “Journal of Cosmetic Dermatology” In this study, researchers found that type A botulinum toxin injections can reduce hypertrophic scars effectively, though more high-quality studies are needed to confirm the precision and stability of these therapeutic effects.
October 2017 in “Dermatologic Surgery” Men are increasingly getting botulinum toxin treatments, requiring higher doses and different techniques than women for a natural look.
January 2025 in “Dermatologic Surgery” This meta-analysis and systematic review found that botulinum toxin injections significantly increased hair count in patients with androgenetic alopecia compared to controls, indicating promising efficacy and good safety.
September 2024 in “Journal of the American Academy of Dermatology” Botulinum toxin is not effective for treating male hair loss.
November 2025 in “Mendeley Data” This study outlines a randomized trial to assess if administering botulinum toxin before hair transplantation can improve outcomes by enhancing blood flow and reducing ischemia-induced graft failure in patients with androgenetic alopecia.
12 citations
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December 2018 in “Dermatologic Therapy” Small Botox dose effectively treats hair loss in Chinese men.
December 2021 in “Intisari Sains Medis” This case report describes a 29-year-old woman with Female Pattern Hair Loss whose hair thinning reduced one month after botulinum toxin treatment.
26 citations
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July 2005 in “Optometry and vision science” This case report documents unilateral madarosis and facial alopecia as potential adverse effects of botulinum A toxin injections in a patient treated for left oromandibular dystonia.
50 citations
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November 2010 in “Plastic and Reconstructive Surgery” This study suggests that Botox injections may increase hair count and reduce hair loss in men with androgenetic alopecia, potentially through increased blood flow and oxygen to the scalp.
February 2025 in “Journal of Cosmetic Dermatology” This case report describes a 34-year-old Asian female who experienced prolonged localized facial blanching following botulinum toxin type A injection, marking the first such documented case in this population.
3 citations
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February 2023 in “BMJ Case Reports” This case report describes a woman with trichotillomania who experienced marked improvement and hair regrowth after off-label onabotulinumtoxinA treatment.
1 citations
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April 2023 in “International Journal of Molecular Sciences” This study found that Botryococcus terribilis ethanol extract significantly reduced inflammation markers in LPS-stimulated RAW264 cells, potentially via Axl inhibition and alteration of immune-related gene expression.
12 citations
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January 2016 in “Skin appendage disorders” This study reports that women receiving periodic injections of botulinum toxin type A for forehead wrinkles may experience frontal alopecia, with progressive hairline recession observed in the cases studied.
September 2023 in “JPRAS Open” This review discusses botulinum toxin A as a treatment for various types of hair loss and reports no clinical results; the authors emphasize the need for comprehensive evaluations and further research.
March 2023 in “JAAD case reports” In this study, researchers reported that conventional treatments for folliculitis decalvans, which include steroids and antibiotics, are often ineffective, with many patients experiencing frequent recurrences of this scarring scalp disorder.
July 2024 in “Forum Dermatologicum”
April 2016 in “Journal of Clinical Research in Dermatology” This report describes a case of sclero-atrophy localized to the frontal scalp following an injection of botulinum toxin type A, which has not been previously documented in the literature.
January 2026 in “Dermatologic Therapy” In this systematic review and meta‐analysis, botulinum toxin monotherapy was found to significantly increase hair density in patients with androgenetic alopecia, with optimal effects observed using a 100-unit dose every six months. These findings suggest potential efficacy but should be confirmed in larger, placebo-controlled trials.
2 citations
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July 2022 in “Dermatologic Therapy” This study concluded that both botulinum toxin A and multivitamins mesotherapy effectively treat telogen effluvium, but a single botulinum toxin A session may be preferable due to its convenience and comparable efficacy.
15 citations
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April 2020 in “Journal of The American Academy of Dermatology” In this study, intradermal injection of botulinum toxin was associated with increased hair growth in men with androgenetic alopecia through the suppression of TGF-β1 secretion from dermal papilla cells.
1 citations
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January 2016 in “Royal Devon and Exeter Research Repository (Royal Devon and Exeter)” This article reviews the potential link between botulinum toxin treatment and alopecia but provides no new research findings.
Botulinum toxin-A injections in the scalp can reduce hair loss and promote new hair growth in men with certain types of baldness.
September 2024 in “Journal of the American Academy of Dermatology” Botulinum toxin is not effective or cost-efficient for treating male pattern baldness.