The Efficacy of Botulinum Toxin in the Treatment of Androgenetic Alopecia: A Meta-Analysis

    January 2026 in “ Dermatologic Therapy ”
    Haiyan Weng, Pengfei Cha, Yan Wan … Yang Chen
    Studysummary In this systematic review and meta‐analysis, botulinum toxin monotherapy was found to significantly increase hair density in patients with androgenetic alopecia, with optimal effects observed using a 100-unit dose every six months. These findings suggest potential efficacy but should be confirmed in larger, placebo-controlled trials.
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    Research cited in this study 7

    1. Effects and Safety of Botulinum Toxin Injection in Treatment of Androgenetic Alopecia: A Meta-Analysis and Systematic Review Dermatologic Surgery · 2025
    2. Efficacy of Type A Botulinum Toxin Treatment for Androgenetic Alopecia Using Ultrasound Combined with Trichoscopy Skin Research and Technology · 2024
    3. Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on Botulinum Toxin for Androgenetic Alopecia Dermatology and therapy · 2024
    4. Treatments for Alopecia Areata: A Network Meta-Analysis The Cochrane library · 2023
    5. Botulinum Toxin A for Hair Loss Treatment: A Systematic Review of Efficacy, Safety, and Future Directions JPRAS Open · 2023
    6. Effectiveness of Platelet-Rich Plasma in the Treatment of Androgenic Alopecia: A Meta-Analysis Aesthetic Plastic Surgery · 2023
    7. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022