Effects of Botulinum Toxin Type A on Histamine-Induced Itch and Vasomotor Responses in Human Skin

May 2008 in “ Toxicon ”

Parisa Gazerani, Natalia Spicina Pedersen, Asbjørn Mohr Drewes, Lars Arendt-Nielsen

botulinum toxin type A histamine-induced itch neurogenic inflammation vasomotor responses flare area blood flow pruritic conditions hair follicle regeneration alopecia Botox itch inflammation itchy skin hair growth hair loss

TLDR Botulinum toxin type A reduces itch and inflammation from histamine and may help treat certain skin conditions and hair loss.

In a study from 2008, Botulinum toxin type A (BONT/A) was found to significantly reduce histamine-induced itch intensity and neurogenic inflammation in human skin. Fourteen healthy male volunteers received BONT/A injections and were subjected to histamine-prick tests at various intervals. The results showed that BONT/A (5 U) notably decreased both the itch intensity and the vasomotor responses such as flare area and blood flow compared to saline. These findings suggest that BONT/A could be used in future treatments for certain pruritic conditions. Additionally, the document mentions a separate study on mice, which found that a single microinjection of BONT/A into the alopecic area significantly reduced hair loss and stimulated hair follicle regeneration, indicating potential applications for treating various forms of alopecia.

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research Effects of Botulinum Toxin Type A on Histamine-Induced Itch and Vasomotor Responses in Human Skin

May 2008 in “Toxicon”

Botulinum toxin type A reduces itch and inflammation from histamine and may help treat certain skin conditions and hair loss.