This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”
This study observed that mice lacking epidermal HSD11b1 had increased non-histaminergic itch and changes in skin nerve fibers, potentially linked to higher TSLP expression.
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June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”
This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.
A user with hair loss issues is considering switching treatments to oral minoxidil and dutasteride due to unsatisfactory results with finasteride and is experiencing itchy scalp and pimples. Suggestions include seeing a dermatologist, using salicylic acid shampoo, and considering dietary changes.
The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.
The user tried pyrilutamide for hair loss and noticed reduced scalp itch and improved skin but stopped due to mild heart sensations. They plan to update after consistent use, noting improved sleep when applied at night.
The conversation discusses using isotretinoin (Accutane) to reduce scalp oiliness and manage scalp issues like seborrheic dermatitis, inflammation, and chronic itch. A user shares that taking 20mg of Accutane every other day effectively reduces oily hair and skin.
Lowering DHT can improve skin quality and reduce scalp issues. Finasteride is effective for hair regrowth and improving skin texture, while dutasteride may increase oiliness and shedding for some users.