The Impact of Botulinum Toxin on Hair Transplantation Outcomes: A Split-Scalp Randomized Controlled Trial

This study investigates the impact of botulinum toxin (BoNT) on hair transplantation outcomes through a split-scalp randomized controlled trial. BoNT, known for its cosmetic and therapeutic uses, may enhance hair transplantation by improving the scalp microenvironment, increasing local oxygenation, and blood flow, thus reducing ischemia-induced graft failure. The study focuses on androgenetic alopecia (AGA) patients, particularly those with male pattern hair loss (MPHL) and congenital high hairline (CHHL). The hypothesis is that perioperative BoNT administration could improve graft survival and hair transplantation success. The trial aims to provide evidence for BoNT's potential to enhance hair transplantation outcomes.