14 citations
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December 2024 in “Pharmaceutics” This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.
14 citations
,
November 2022 in “Archives of Dermatological Research” This study found that a green-light LED microneedle patch enhanced hair growth in mice with the best results among tested wavelengths, showing increased hair follicles and no serious side effects, suggesting its potential for treating androgenetic alopecia.
14 citations
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February 2022 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.
14 citations
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June 2021 in “Archives of Dermatological Research” In this study, researchers evaluated the use of adipocyte-derived stem cell conditioned media combined with fractional laser or microneedling for treating refractory alopecia areata, finding that 64.3% of patients had significant hair regrowth, suggesting this combination may be an effective and safe treatment option.
14 citations
,
February 2021 in “International Journal of Pharmaceutics” In this study, applying deer antler velvet extract-loaded niosomes and microspicules serum to the scalp significantly improved hair growth, melanin content, and skin hydration over 14 to 30 days without causing skin irritation.
14 citations
,
January 2021 in “Scientific Reports” This study found that "micro skin tissue columns" improved wound healing by enhancing re-epithelialization, collagen deposition, dermal remodeling, and reducing inflammation without causing long-term donor site morbidity.
14 citations
,
March 2020 in “Scientific Reports” This study found that dual-frequency ultrasound with microbubble cavitation significantly enhanced minoxidil delivery and hair growth in both lab and animal models compared to single-frequency ultrasound, without damaging the skin in mice.
14 citations
,
October 2019 in “Journal of Cellular Physiology” This study found that dermis micrografting improved hair growth and density in patients with androgenetic alopecia over 4, 6, and 12 months, suggesting it could be a novel treatment option.
14 citations
,
August 2019 in “Clinical and Experimental Dermatology” This study suggests that combining microneedling with ALA-photodynamic therapy may be a promising treatment option for moderate to severe alopecia areata, achieving significant hair regrowth in some patients.
14 citations
,
June 2016 in “Biomaterials” This study observed that MAA beads improved vascularization in non-diabetic male mice by modulating the Shh signaling pathway in wound granulation tissue, but showed no such effects in females.
14 citations
,
March 2014 in “Experimental and Molecular Pathology” This study found that sulfur mustard affects hair follicles and sebaceous glands in the skin by causing cellular damage, inflammation, and disrupting wound healing processes in hairless mice.
14 citations
,
October 2002 in “Journal of cutaneous pathology” This study found that MAP-2 is intensely expressed in the companion layer of the hair follicle, suggesting its potential importance to follicle integrity and possible involvement in some types of alopecia.
13 citations
,
September 2011 in “Archives of dermatology” This case report describes a 3-year-old male with X-linked ichthyosis and associated neurologic abnormalities, identifying an unusual cortical development malformation and suggesting that abnormal hair banding may assist diagnosis.
13 citations
,
November 2022 in “Biomaterials Science” This study demonstrated that a device combining hyaluronic acid-based dissolving microneedles and lipid polymer hybrid nanoparticles effectively delivered miR-218 to promote hair growth in a shaved mouse model, outperforming topical smear treatment without safety concerns.
13 citations
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April 2022 in “BMC Genomics” This study found that dandruff-afflicted individuals had a less integrated microbial network on the scalp and hair surface compared to healthy individuals, with more positive interactions and unstable connections.
13 citations
,
January 2022 in “Microvascular Research” This study found that high-resolution laser speckle contrast imaging devices provide good reproducibility for assessing skin perfusion in mice but not for measuring haemoglobin oxygenation.
13 citations
,
January 2022 in “Advances in Dermatology and Allergology” This review discusses the relationship between gut microbiota and alopecia areata, and it does not report new clinical results.
13 citations
,
September 2021 in “Communications Biology” This study introduces a five-modal microscopy technique that allows label-free, in vivo observation and quantitative analysis of various wound healing processes.
13 citations
,
September 2020 in “Dermatologic Therapy” This review discusses the use of microneedling for androgenetic alopecia and finds it promising for enhancing hair density and thickness, especially when combined with other treatments, but notes no standardized protocol exists yet.
13 citations
,
February 2020 in “Journal of the American Academy of Dermatology” This study found that both oral tranexamic acid and microneedling improve melasma treatment outcomes when added to standard therapy, with microneedling showing a more sustained remission.
13 citations
,
September 2018 in “Scientific Reports” In this study, researchers found that microRNAs and specific target genes, such as MiR-195 and genes like CHP1, SMAD2, FZD6, and SIAH1, play significant roles in regulating hair follicle initiation in cashmere goats.
13 citations
,
January 2016 in “Journal of the Egyptian Women's Dermatologic Society (Print)” This abstract discusses platelet-rich plasma therapy for patterned hair loss but provides no new clinical results, suggesting further research is needed to determine its effectiveness.
13 citations
,
July 2012 in “International Journal of Trichology” In this study, the varied phenotype of trichothiodystrophy was highlighted, with findings of distinctive hair shaft abnormalities and a wide range of multisystem issues, including neurologic and urologic disorders.
13 citations
,
January 2001 in “Skin pharmacology and physiology” This article discusses a new device for visualizing and quantifying skin distribution of a radioactively labelled compound, but reports no new clinical results.
12 citations
,
April 2025 in “Discover Pharmaceutical Sciences” This review examines microneedle patches for drug delivery, detailing their designs, materials, manufacturing methods, and potential advantages, but reports no new clinical results.
12 citations
,
September 2024 in “JID Innovations” This review highlights the potential of microfluidic skin-on-a-chip models in skin research, emphasizing their ability to mimic human skin structure and improve control over cellular and molecular distribution compared to traditional in vitro models.
12 citations
,
April 2023 in “Molecular Pharmaceutics” This study demonstrated that a microarray patch can deliver antibodies in a controlled and prolonged manner, maintaining their functionality after manufacturing and heat exposure, with successful pharmacokinetic proof-of-concept in rats.
12 citations
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August 2022 in “Journal of Controlled Release” In this study, a microneedle patch containing conditioned media from hypoxia-pretreated stem cells enhanced hair regeneration in an androgenetic alopecia mouse model by boosting perifollicular vascularization and hair follicle stem cell activation compared to minoxidil.
12 citations
,
February 2022 in “Acta Biomaterialia” In this study, researchers found that dissolving microneedles made with hyaluronic acid enhanced the effectiveness of minoxidil in reducing hair loss and promoting hair growth in alopecia-affected mice more effectively than topical minoxidil alone, while using only 10% of the drug amount.
12 citations
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November 2020 in “Journal of Dermatological Science” In this study, miR-324-3p was found to promote differentiation and migration in cultured keratinocytes and is highlighted as a potential target for treating androgenic alopecia.