A 9-year-old girl developed type 1 diabetes and alopecia after being treated for a rare kidney disease.
Naproxen can cause serious lung issues, but high-dose aspirin might be safer.
February 2016 in “Annals of the Rheumatic Diseases” All four treatments for early rheumatoid arthritis had similar and mostly mild side effects.
18 citations,
January 2016 in “Journal of Clinical Medicine Research” A woman with lupus and severe nerve damage improved with specific treatments.
1 citations,
September 2022 in “F1000Research” A 56-year-old man with no prior history of conditions typically associated with digital gangrene presented with systemic lupus erythematosus (SLE) and digital gangrene as one of the initial symptoms. He exhibited joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Laboratory tests showed lymphocytopenia and elevated C-reactive protein, with positive antinuclear antibodies. Despite initial treatment with hydroxychloroquine, methylprednisolone, cyclophosphamide, and calcium blockers, the lesions did not improve. However, after two infusions of rituximab, there was a significant improvement in vasculitis lesions and partial improvement in dyspnea. This case highlights digital gangrene as a rare primary manifestation of late-onset SLE.
August 2024 in “Intisari Sains Medis” A 17-year-old girl with systemic lupus erythematosus (SLE) presented with a seizure and subsequent loss of voice, alongside symptoms like severe hair loss, fever, and various hematological abnormalities. MRI showed brain atrophy, and echocardiography revealed mild carditis and pericardial effusion. Immunological tests confirmed SLE. Fiberoptic laryngoscopy identified bilateral vocal cord palsy due to SLE. Treatment with high-dose methylprednisolone, cyclophosphamide, and speech therapy led to gradual improvement in her speech. Continuous monitoring is necessary for complete resolution of the vocal cord palsy.
November 2023 in “Gastroenterology” A woman with Budd-Chiari syndrome improved after treatment and needs a liver transplant, highlighting the importance of considering non-criteria antiphospholipid syndrome in similar cases.
October 2023 in “CHEST Journal” A 15-year-old female with systemic lupus erythematosus (SLE) presented with lupus nephritis, cerebritis, and diffuse alveolar hemorrhage (DAH). Initial symptoms included joint pain, facial redness, fatigue, and hair loss. Lab tests showed high antinuclear and double-stranded DNA antibodies. Despite treatment with methylprednisolone, she developed severe symptoms including headache, fever, vision loss, and hemoptysis. Cyclophosphamide treatment led to significant improvement. DAH, a rare but serious SLE complication, should be suspected in SLE patients with progressive dyspnea, desaturation, and hemoglobin decrease. The case highlights the importance of early recognition and treatment to improve outcomes.
A 29-year-old woman was diagnosed with ANA-negative Systemic Lupus Erythematosus (SLE) presenting with segmental hyalinizing vasculitis and valvular heart disease. Despite the absence of antinuclear antibodies, her symptoms and clinical findings, including painful skin ulcers, joint pain, fever, and heart issues, met the criteria for SLE. Treatment with hydroxychloroquine, methylprednisolone, and desoximethasone cream led to significant clinical improvement and complete resolution of skin ulcers after 6 months, highlighting the importance of early recognition and aggressive therapy in this rare SLE subset.
March 2023 in “International Journal of Dermatology” A 51-year-old woman developed a nonpruritic urticated rash following a COVID-19 infection, which led to a diagnosis of systemic lupus erythematosus (SLE) with associated symptoms including pericarditis, hypertension, and renal impairment. Histopathology and serology indicated possible neutrophilic urticarial dermatosis (NUD) or hypocomplementemic urticarial vasculitis syndrome (HUVS). The patient later experienced central nervous system vasculitis, treated successfully with methylprednisolone, intravenous immunoglobulin, and plasma exchange. This case underscores the importance of considering serious systemic diseases in patients with nonpruritic urticated rashes and highlights the need for comprehensive serological testing and biopsy for accurate diagnosis and early treatment.
August 2022 in “F1000Research” A 56-year-old man with no prior risk factors presented with systemic lupus erythematosus (SLE) and digital gangrene as initial symptoms. He exhibited joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Laboratory tests showed lymphocytopenia and elevated C-reactive protein, with positive antinuclear antibodies. Pulmonary tests indicated fibrosis and restrictive disease. Despite initial treatment with hydroxychloroquine, methylprednisolone, cyclophosphamide, and calcium blockers, the lesions persisted. Rituximab infusions led to significant improvement in vasculitis lesions and partial relief of dyspnea. This case highlights digital gangrene as a rare primary manifestation of late-onset SLE.
October 2011 in “Reactions Weekly” A man had a severe allergic reaction to sulfasalazine, with symptoms improving after treatment and follow-up.
52 citations,
March 2009 in “Journal of the American Academy of Dermatology” A 93-year-old woman developed a rare scalp condition after therapy, which improved with steroids, not antibiotics.
23 citations,
April 2002 in “Journal of the American Academy of Dermatology” Depigmented hair regrowth after alopecia areata can be permanent.
19 citations,
October 2013 in “Headache: The Journal of Head and Face Pain” The document concludes that inhalation of oxygen and sumatriptan injections are primary for cluster headaches, indomethacin for paroxysmal hemicrania, and lidocaine and lamotrigine for SUNCT, but SUNCT often resists treatment.
1 citations,
May 2015 in “Journal of The American Academy of Dermatology” Lichen planus pigmentosus and fibrosing frontal alopecia in Colombia are likely different stages of the same disease.
May 2015 in “Journal of The American Academy of Dermatology” Some people may temporarily lose more hair in certain areas after a hair transplant.
May 2015 in “Journal of The American Academy of Dermatology” The Nd:YAG laser is a successful and safe way to treat ingrown and pincer nails.
April 2008 in “Companion Animal” The cat's skin condition was linked to cancer and did not improve with treatment, leading to a poor outcome.
115 citations,
June 2004 in “Pediatrics” Children, especially teenagers, can get severe SARS-CoV infection with symptoms similar to adults, but they typically recover well with supportive care.
99 citations,
July 2017 in “Clinical Reviews in Allergy & Immunology” New treatments for Alopecia Areata show promise but need to be more effective and affordable.
17 citations,
April 1975 in “The Journal of Pediatrics” Minoxidil effectively controls severe high blood pressure in children with few side effects.
15 citations,
October 1981 in “Archives of internal medicine” Minoxidil can cause severe skin reactions like Stevens-Johnson syndrome in rare cases.
13 citations,
April 2020 in “Dermatology and therapy” Cyclosporine combined with corticosteroids is more effective for severe alopecia areata than cyclosporine alone.
10 citations,
September 2014 in “European Journal of Dermatology” A woman's hair loss worsened after starting hepatitis C treatment due to immune changes in her hair follicles.
8 citations,
September 2011 in “European Journal of Dermatology” Most treatments for Frontal Fibrosing Alopecia are ineffective, but early anti-inflammatory therapy may help and the condition may stabilize over time.
7 citations,
March 2014 in “ISRN Biomaterials” Keratin hydrogel from human hair helps rats recover better from spinal cord injuries.
7 citations,
February 2011 in “Journal of The American Academy of Dermatology” Most women with hyperandrogenism first show acne, and skin conditions like hirsutism and acanthosis nigricans are good indicators of the condition.
5 citations,
January 2017 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” Porokeratotic eccrine and hair follicle nevus is a very rare skin disorder possibly caused by a GJB2 gene mutation.
3 citations,
July 2008 in “British journal of dermatology/British journal of dermatology, Supplement” Terbinafine can cause hair loss.