November 2025 in “Cosmetics” This study found that of the many ingredients advertised in shampoos as effective against hair loss, only caffeine, adenosine, placental proteins, and melatonin have limited clinical evidence supporting their efficacy, with most claimed active ingredients lacking any trial-based validation.
July 2023 in “International Journal of Cosmetic Science” This article reviews how biopolymers are utilized in cosmetics, highlighting their biodegradable and non-toxic properties, recent structural developments, novel applications, and safety considerations in the formulation of skin, hair, and oral care products.
14 citations
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January 2012 in “International Journal of Dermatology” This case report describes oleoma on the thighs and buttocks appearing two years after an injection for cellulite treatment, suggesting the need for more research to ensure the procedure's safety and efficacy.
5 citations
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July 2025 in “Journal of Clinical Medicine” This study reviewed existing literature on mesotherapy and developed evidence-based guidelines, which support its standardized and safe use for osteoarticular pain, rehabilitation, and dermatology, marking a shift from practice based on personal beliefs to an evidence-based approach.
April 2024 in “Medicina Estética Revista Científica de la Sociedad Española de Medicina Estética (SEME)” This study clarifies the fundamental aspects of intradermotherapy or mesotherapy, tracing its historical development and highlighting its benefits as well as the negative consequences of improper use, specifically addressing its decline due to severe side effects from treatment errors.
49 citations
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May 2020 in “The Scientific World JOURNAL” This position paper from the Italian Mesotherapy Society discusses the application of intradermal therapy based on scientific evidence, highlighting its potential benefits for certain localized conditions, although it acknowledges the lack of randomized clinical trials for some uses.
41 citations
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April 2012 in “Journal of The European Academy of Dermatology and Venereology” This study found that mesotherapy with a dutasteride-containing preparation improved hair growth indicators in female pattern hair loss better than saline, with minimal side effects and greater effectiveness in patients with shorter disease duration.
24 citations
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January 2017 in “International Journal of Trichology”
20 citations
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August 2019 in “Journal of Cosmetic Dermatology” This study reviewed literature from 1992 to 2018 to document mesotherapy-related complications and their management, concluding that standardized therapy parameters are needed to better evaluate the safety profile and minimize risks of adverse reactions.
11 citations
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May 2019 in “Journal of Cosmetic Dermatology” This case report observed significant improvement in hair density and thickness in a male patient with androgenetic alopecia following the addition of mesotherapy, alongside topical minoxidil and oral finasteride, over 20 sessions, with no side effects reported.
11 citations
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January 2019 in “International Journal of Trichology” This study observed no significant improvement of mesotherapy over 5% topical minoxidil for male androgenic alopecia, despite a small increase in hair shaft diameter variation with mesotherapy.
8 citations
,
March 2022 in “Journal of Cosmetic Dermatology” This study concluded that mesotherapy appears effective for treating pattern hair loss, but emphasizes a need for more research comparing it to other treatments due to limited sample sizes.
8 citations
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January 2008 in “PubMed” This study reports that mesotherapy can lead to serious complications, such as multifocal scalp abscesses and subcutaneous fat necrosis, requiring extensive surgical repair.
6 citations
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November 2017 in “Journal of the European Academy of Dermatology and Venereology” A woman got melanoma on her scalp after anti-hair loss treatment with injections.
5 citations
,
February 2021 in “Gels” In this study, HYDRO DELUXE BIO was reported to show promise for scalp mesotherapy by enhancing angiogenesis and reducing inflammation in an in vitro model.
5 citations
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February 2021 in “Dermatology and Therapy” This study found that two sessions of platelet-rich plasma mesotherapy significantly improved symptoms in patients with corticosteroid-induced rosacea-like dermatitis without further treatment.
5 citations
,
July 2020 in “Journal of Cosmetic Dermatology” This study found that using a vibration anesthetic device during scalp mesotherapy significantly reduced pain in patients with androgenetic alopecia and alopecia areata compared to the non-vibration side.
4 citations
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December 2021 in “Dermatologic Therapy” This study reported 14 cases of frontal edema following mesotherapy for androgenetic alopecia, suggesting clinicians should be aware of this potential side effect.
3 citations
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June 2007 in “CRC Press eBooks” Mesotherapy might be an effective treatment for hair loss.
2 citations
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April 2017 in “Health technology assessment in action” This study reviewed previous research and found that while mesotherapy appears to improve outcomes in treating androgenetic alopecia without significant adverse effects, the supporting studies were of poor quality, and further research is necessary to confirm its efficacy and safety.
2 citations
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May 2015 in “International Journal of Scientific Reports” In this observational study, 95% of androgenetic alopecia patients treated with neonatal mesenchymal stem cells through mesotherapy showed mild to moderate improvement in hair growth and reduction in hair loss.
2 citations
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March 2014 in “Turkderm” Mesotherapy and platelet-rich plasma treatments may help with hair loss, but their safety and effectiveness are still uncertain.
1 citations
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August 2019 in “IntechOpen eBooks” This article discusses the use of mesotherapy in dentistry and reports no new clinical results, emphasizing the need for further research on its applications for oral problems.
1 citations
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August 2018 in “Journal of The American Academy of Dermatology” Dutasteride and minoxidil mesotherapy effectively treats hair loss with minimal side effects.
1 citations
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January 2012 in “Springer eBooks” Mesotherapy can cause serious side effects like infections and skin reactions.
1 citations
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January 2010 This study found that using minoxidil 2% as a mesotherapy injection showed more significant improvement in treating androgenetic alopecia in female patients than topical application.
July 2026 in “Innovations in Pharmaceutical Sciences & Care” In this case report, a 31-year-old man with frontal hairline recession saw a marked improvement in hair density and scalp appearance after undergoing six mesotherapy sessions alongside twice-daily application of 5% minoxidil, attributed to the treatment protocol combining nutrients, bioactives, and topical minoxidil.
July 2026 in “Health Science Reports” This study evaluated the efficacy and safety of microneedling combined with mesotherapy for androgenic alopecia and found that combination protocols, particularly those including both finasteride and latanoprost, showed the highest efficacy, especially among women and younger participants.
March 2026 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This study reports that perioperative use of dutasteride, both orally and through mesotherapy, may enhance hair graft survival and reduce shock loss in patients undergoing hair transplantation for androgenetic alopecia.