Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

    May 2020 in “ The Scientific World JOURNAL
    Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Di Giorgio, Gianpaolo Ronconi, Paola Emilia Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, U. Massafra, Barbara Bifarini, Fabio Gori, Massimo Di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli
    TLDR Mesotherapy is a skin injection therapy used for pain and local conditions, with scientific support but needing more clinical trials.
    Mesotherapy, an intradermal therapy involving drug injection into the skin's surface layer, was used to treat localized pain syndromes and other local conditions by modulating drug kinetics for prolonged action. It was recommended when systemic drug-sparing effects were needed, other therapies failed, or when it could synergize with other treatments. Although lacking randomized clinical trials in some areas, there was a consensus on its nonpharmacological mechanisms, execution, and scientific rationale. The Italian Mesotherapy Society aimed to base its application on scientific evidence rather than personal bias.
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