Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

    May 2020 in “ The Scientific World JOURNAL
    Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Di Giorgio, Gianpaolo Ronconi, Paola Emilia Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, U. Massafra, Barbara Bifarini, Fabio Gori, Massimo Di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli
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    Studysummary This position paper from the Italian Mesotherapy Society discusses the application of intradermal therapy based on scientific evidence, highlighting its potential benefits for certain localized conditions, although it acknowledges the lack of randomized clinical trials for some uses.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reviewed mesotherapy, a technique involving intradermal drug injections, highlighting its historical development, technique, and potential benefits for localized pain management and conditions like alopecia. It noted that mesotherapy could provide significant pain relief with reduced medication and fewer adverse events compared to systemic treatments, due to both pharmacological and mechanical effects. Despite its widespread use, there was a lack of randomized studies on injection depths, and the efficacy varied with different drugs and conditions. The document emphasized the need for individualized treatment plans, safety concerns, and qualified professionals to perform the procedure. It also discussed the economic benefits and future prospects of mesotherapy, suggesting it could become a method to study drug-skin interactions, with further research needed to understand its therapeutic value.
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