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In this study, activation of c-MycER in adult mouse epidermis rapidly induced proliferation and disrupted keratinocyte differentiation, causing changes similar to precancerous lesions, which regressed once c-MycER was deactivated.

This study reported that discarded squid ink was used to develop a high-performance, environmentally friendly hair dye that offers a stable deep black color, UV protection, and preserves hair structure, while showing excellent biosafety in lab tests.

This paper discusses the need for a standardized classification and meta-analysis of treatments for hypopigmented disorders and reports no new clinical results.

In this study, polydopamine emerged as a safe and effective alternative to traditional hair dyes like PPD for dyeing gray hair permanently, showing resistance to detergents and causing less toxicity and hair loss in mice.

This study identified seven genes that may serve as biomarkers for diagnosing skin cutaneous melanoma by analyzing the relationship between UV exposure, ferroptosis, and the cancer's pathology.

This study found that exogenous ochronosis from hydroquinone use in melasma treatment has distinctive dermatoscopic features that may aid in diagnosis without needing a biopsy.

The researchers designed a Janus microneedle system for treating vitiligo, which targets the skin’s layers to regulate the immune response, promote melanocyte regeneration, and enhance pigment transfer, offering a new precise treatment approach for this condition.

This study found that melatonin may enhance hair growth properties in dermal papilla cells by activating the AKT/GSK3β/β-catenin signaling pathway through melatonin receptors.

This report discusses a case of an intradermal nevus in a 42-year-old woman and provides no clinical findings beyond a biopsy showing hyperkeratosis and cellular pigmentary changes.

This review highlights advancements in vitiligo treatment, noting improved diagnostic techniques and the emergence of targeted therapies like Janus Kinase inhibitors, which may offer more effective management of this complex autoimmune skin disorder.

This study found that no patients with moderately dysplastic nevi with positive margins developed melanoma at the biopsy site, but those with a history of multiple nevi may have a higher risk of melanoma elsewhere.

This study suggests that systemic exposure to black eyeliner pigment may occur, potentially leading to permanent eyelash loss following the procedure.

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

In this study, phenylthiocarbamide intake was associated with hair graying in rats, while switching to tap water led some rats to regain their original fur color, suggesting dietary factors influence pigmentation.

This review highlights the potential of combining immune regulation, phototherapy, and dietary strategies for effective vitiligo treatment, but emphasizes that more research is needed.

This study observed that 5α‐dihydrotestosterone increased pigmentation in certain skin areas of male Syrian hamsters, while estradiol decreased melanocyte numbers and counteracted the androgen-induced pigmentation effects.

This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.

This study suggests that in gp91phox-knockout mice, tranexamic acid administration led to brown hair by increasing MGRN1 and collagen XVII levels, while the retention of black hair appears to rely on the gp91phox/ROS/IL-1β/TGF-β pathway.

This study found that lentiginous melanoma had the highest incidence in central facial areas, with men showing higher rates on peripheral head regions and women on central face regions.

Mouse tail skin has different keratinization near hair follicles and scales.

This case report suggests that nonsynchronized segmented heterochromia in black scalp hair in a 14-year-old girl may represent premature greying unrelated to deficiencies in iron, copper, zinc, or protein.

PRAME helps distinguish between benign and malignant skin cells in most cases.

This study found that the Wnt/β-catenin signaling pathway activates melanocyte stem cells, promoting hair follicle regeneration both in vitro and in vivo.

The document concludes that skin and nail changes can indicate various underlying health conditions.

This case report suggests that identifying hyperpigmentation on the upper eyelid with specific dermoscopy patterns could help diagnose facial lichen planus pigmentosus without needing a facial biopsy.

This study reviews various hyperpigmentation disorders, their causes, and evolving treatments, emphasizing the need for safe, effective cosmeceuticals particularly suited for adolescents, integrating botanical and phytochemical advancements with modern dermatological techniques.