The Role of Gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice

The study investigated the role of gp91phox in hair color and the effect of tranexamic acid on hair color in mice. It was found that gp91phox-knockout (gp91phox−/−) mice developed white hair over time, with lower levels of reactive oxygen species, IL-1β, and TGF-β compared to control mice. Administration of tranexamic acid resulted in brown hair in gp91phox−/− mice, despite no changes in melanocortin receptor 1 and agouti signaling protein expression. The treatment increased the expression of mahogunin ring finger protein 1 (MGRN1) and collagen XVII, suggesting that the gp91phox/ROS/IL-1β/TGF-β pathway is crucial for maintaining black hair, while elevated MGRN1 and collagen XVII levels contribute to brown hair in these knockout mice.