The Role of Gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice

The study explored the role of gp91phox and the impact of tranexamic acid on hair color in mice. Gp91phox-knockout mice developed white hair due to reduced levels of ROS, IL-1β, and TGF-β, which are important for maintaining black hair. When treated with tranexamic acid, these mice exhibited brown hair, linked to increased expression of MGRN1 and collagen XVII, despite no changes in melanocortin receptor 1 and agouti signaling protein expression. The study, involving 6 mice per group, suggested that tranexamic acid could influence hair color by affecting the gene controlling MGRN1, indicating potential implications for treating white hair. Further research was recommended to understand the underlying mechanisms.