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GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

research Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond

1 citations , January 2005 in “Experimental Dermatology”

MC-1R in skin cells may influence inflammation and collagen production.

Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations , September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

research The Role of Gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice

2 citations , May 2019 in “International Journal of Molecular Sciences”

Tranexamic acid turns white hair brown in certain mice by affecting specific proteins.

A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation

research A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation

56 citations , November 2010 in “Pigment Cell & Melanoma Research”

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

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