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GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations , September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

research The Role of Gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice

2 citations , May 2019 in “International Journal of Molecular Sciences”

Tranexamic acid turns white hair brown in certain mice by affecting specific proteins.

research Bone Morphogenetic Protein Signaling Controls Hair Pigmentation Through Cross-Talk With the Melanocortin Receptor-1 Pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

research Sebocytes’ Makeup: Novel Mechanisms and Concepts in the Physiology of the Human Sebaceous Glands

58 citations , March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv”

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

research CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice

29 citations , February 2011 in “PloS one”

Astressin-B can reverse and prevent hair loss in stressed mice.

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