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Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Stress can stop hair growth in mice, and treatments can reverse this effect.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Lowering testosterone speeds up wound healing in male mice.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Layer-by-Layer self-assembly is promising for biomedical uses like tissue engineering and cell therapy, but challenges remain in material safety and process optimization.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

Muscles and nerves that cause goosebumps also help control hair growth.

Targeting the skin's endocannabinoid system could help treat skin disorders.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.

Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.