In this study, melatonin implantation altered BMP2 gene expression associated with hair follicle growth in Inner Mongolia Cashmere Goats, particularly reducing expression during the follicles' resting period.
125 citations
,
February 1971 in “Biochemistry” Specific cross-linkages help make hair proteins stable and strong.
February 2026 in “Nature Communications” This study combined spatial and single-cell transcriptomics to identify that hypercontractility of the connective tissue sheath activates PIEZO1 in hair follicles, leading to miniaturization in male androgenetic alopecia, and found that inhibiting this contraction improves hair growth in models.
January 2018 in “journal of applied pharmaceutical science” Biomimetic peptides improved hair growth and increased growth factors in hair follicles for hair loss patients.
November 2022 in “Journal of Investigative Dermatology” This pilot study suggests that lovastatin may counteract stress-induced MICA expression in hair follicles and enhance MICA shedding, potentially offering a complementary approach for alopecia areata treatment.
July 2024 in “Pharmaceutics” In a mouse model of androgenetic alopecia, this study found that a novel hydrogel containing minoxidil-incorporated engineered exosomes (Gel@MNs) enhanced hair regeneration more effectively than conventional minoxidil, increasing hair follicle number and size while reducing skin irritation.
September 2023 in “Journal of microbiology and biotechnology” This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.
34 citations
,
February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.
5 citations
,
January 1985 in “Annals of Nutrition and Metabolism” This study found that different doses of methionine altered the composition of developing tooth germs in newborn rats, with incisor and molar germs affected differently but no statistical difference in body weight.
4 citations
,
January 2013 in “International Journal of Trichology” Monilethrix has no effective treatment, but avoiding hair trauma helps manage it.
This study observed that stimulating the cholinergic system via muscarinic receptors in dermal papilla cells and other hair-related tissues promoted hair growth, with mechanisms involving the activation of Wnt/β-catenin signalling pathways in cell cultures and increased hair shaft elongation in mouse vibrissae treated with bethanechol.
10 citations
,
October 2018 in “Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology” This study identified NM_026333 as a potential anti-aging gene that, when induced, may alleviate proton-induced aging symptoms in CF6-overexpressing and high salt-fed mice.
28 citations
,
November 2020 in “Journal of Controlled Release” In this study, microneedles combined with finasteride nanostructured lipid carriers (FIN-NLC-MNs) were found to enhance skin penetration and specifically target hair follicles, promoting hair growth and gene regulation in androgenetic alopecia.
December 2025 in “Frontiers in Veterinary Science” This study found that PT-LCG extends hair follicle activity and promotes continuous cashmere growth by enhancing lipid synthesis, remodeling the extracellular matrix, and modulating inflammatory signaling, offering insights into improving cashmere yield and quality through molecular breeding.
February 2025 in “BMC Genomics” This study found that in cashmere goats, melatonin treatments enhanced cashmere growth by stimulating secondary hair follicles, increasing follicle density, and improving yield and quality, highlighting key genes and metabolic pathways involved in this process.
April 2025 in “Journal of Pharmaceutical Investigation” In this study, injectable microdepots containing rapamycin and poly(lactic-co-glycolic acid) were developed and demonstrated to effectively promote hair regrowth in mice by sustaining drug release and inducing anagen phase transition in hair follicles through modulating autophagy and the Wnt/β-catenin pathway.
13 citations
,
January 1997 in “Biochemical Pharmacology” This study found that human liver dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of minoxidil, indicating another pathway contributing to its metabolism in humans.
133 citations
,
November 2018 in “Aging” This study identified Azithromycin and Roxithromycin as novel senolytic antibiotics that effectively target and reduce senescent human fibroblast cells.
July 2026 in “Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms”
July 2023 in “Frontiers in Veterinary Science” This study found that exogenous melatonin binds to the nuclear receptor RORα in Inner Mongolia cashmere goats, stimulating secondary hair follicle development and promoting villus growth.
March 2016 in “Institutional Repositories DataBase (IRDB)” This study discusses the effects of collagen hydrolysates and the dipeptide Pro-Hyp on gene expression related to hair and epidermis development in mouse skin and reports no new clinical results.
September 2021 in “C&EN global enterprise” In this study using animal models, microneedle patches loaded with artificial enzymes effectively treated androgenic alopecia, achieving results comparable to the over-the-counter drug minoxidil.
3 citations
,
November 2022 in “Frontiers in molecular biosciences” This study suggests that in mice, plasmalogens may enhance hair growth by activating TRPC4 channels, which increases calcium influx and subsequently stimulates AMPK in hair follicles.
29 citations
,
January 2010 in “Journal of oleo science” In this study, mannosylerythritol lipids from soybean oil notably increased fibroblast and papilla cell viability, suggesting potential as a hair growth agent.
11 citations
,
September 2012 in “Journal of animal physiology and animal nutrition” This study demonstrated that mink hair growth and pelt quality significantly depend on dietary protein levels and DL-methionine supplementation during the growing-furring period.
April 2023 in “Journal of Drug Delivery Science and Technology” This study reported that optimized transfersomes and their gel form significantly improved transdermal delivery and hair growth promotion of minoxidil in C57BL/6 mice compared to commercial formulations.
January 2023 in “Reactions Weekly” March 2023 in “Reactions Weekly” January 2023 in “Reactions Weekly” January 2023 in “Reactions Weekly”