59 citations,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.
14 citations,
June 2014 in “Journal of Pharmaceutical Sciences” Formulation P-08-016 better targets hair follicles for baldness treatment.
7 citations,
February 2016 in “Dermatology and therapy” t-Flavanone helps improve male pattern hair loss by making hair roots stronger.
2 citations,
May 2015 in “Journal of Cosmetic and Laser Therapy” Hair follicles can survive for a few days before transplant but are less viable over time.
2 citations,
January 1980 in “Acupuncture & electro-therapeutics research” Hair loss might be due to nerve issues, treatable with electric stimulation or acupuncture.
September 2023 in “Nature Communications” Rare genetic variants in five specific genes are linked to male-pattern hair loss but only account for a small part of the risk.
May 2023 in “Experimental Dermatology” The study on male pattern hair loss (MPHL) suggests that the localized miniaturization of hair follicles in the frontal and parietal regions of the scalp may be due to their developmental origins. Frontal scalp follicles, which are more sensitive to androgens like dihydrotestosterone (DHT), show higher expression of androgen receptors (AR) and 5α-reductase compared to occipital follicles. This difference is potentially rooted in the fact that frontal scalp fibroblasts and bones derive from neural crest cells, while occipital regions are mesoderm-derived. The authors propose that future research using induced pluripotent stem cells (iPSCs) and direct reprogramming of fibroblasts could further elucidate these developmental differences and their impact on androgen sensitivity, emphasizing the need to specify scalp location in hair follicle research.
251 citations,
October 2006 in “Plastic and reconstructive surgery/PSEF CD journals” Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.
June 2024 in “International journal of molecular sciences” Adenosine complex helps increase hair thickness and density in hair loss.
July 2016 in “Human & Experimental Toxicology” A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.
January 2011 in “Kufa Medical Journal” Minoxidil solution applied on skin can effectively promote hair growth and increase hair thickness in male mice.
May 2013 in “Trends in Urology & Men's Health” Male-pattern hair loss is normal, often involves hormone effects on hair follicles, and can be treated with medication or surgery, but new treatments are being researched.
January 2020 in “Journal of Genetics and Gene Therapy” The document discussed the use of autologous human hair follicular stem cells combined with Platelet Rich Plasma (PRP) for treating androgenetic alopecia in both men and women, particularly in Asian populations. The combination therapy showed promise by utilizing micrografts of human hair follicles, which facilitated tissue remodeling and regeneration through the activation of fibroblasts and mesoangioblasts. Regenera micro-grafts, measuring 70-80 microns, contained essential components of the Tissue Engineering Triangle, including stromal vascular fractions, extracellular matrix, and growth factors, which contributed to the treatment's effectiveness.
1 citations,
June 2021 in “Singapore Medical Journal” Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.
1 citations,
October 2021 in “Gene, cell and tissue” Grape sap may help reduce hair loss and promote hair growth in rats.
February 2024 in “International Journal of Molecular Sciences” Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.
January 2012 in “Human health handbooks” Low-level light therapy is FDA-approved for male pattern hair loss, increases hair count and strength, and is considered safe for use.
80 citations,
April 2006 in “Clinical Interventions in Aging” Minoxidil and Finasteride are effective for male baldness; more research is needed for hair aging treatments.
47 citations,
January 2001 in “Journal of Investigative Dermatology” High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.
17 citations,
October 2013 in “Plastic and reconstructive surgery. Global open” Male pattern baldness may be caused by scalp pressure on hair follicles, which increases with age and leads to a cycle of hair loss. This process is not directly determined by genes.
17 citations,
December 2004 in “The Journal of Men's Health & Gender” Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.
8 citations,
October 2008 in “Medical hypotheses” Baldness might be caused by scalp weight pressing on hair follicles.
5 citations,
September 1998 in “Atlas of the oral and maxillofacial surgery clinics of North America” Hair transplantation and micrografting, used for baldness, involve moving hair follicles from hair-rich to bald areas, requiring careful procedure and post-care for success.
September 2023 in “Biomedical Optics Express” New imaging techniques show testosterone delays hair growth and shrinks follicles in mice, but have limited depth for viewing.
January 2021 in “Figshare” Metformin helps regenerate hair follicles in lab conditions.
4 citations,
August 2018 in “Journal of Cosmetic Dermatology” Actual harvested hair follicles were fewer and differed in type from estimated, with older patients and those with multiple transplants needing more careful planning.
January 2022 in “Stem cell biology and regenerative medicine” Dermal sheath cells can help grow new hair follicles and show promise in treating hair loss.
January 2022 in “Biomedical Reports” Inaudible sound at 30 kHz can boost hair growth and decrease hair loss by promoting cell growth and reducing cell death in hair follicles.
183 citations,
January 2014 in “BioMed Research International” AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.
65 citations,
August 2007 in “Experimental Dermatology” Human hair follicles can make and process prostaglandins, which may affect hair growth.