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This study found that patients with androgenic alopecia had altered neuroactive steroid levels and depression symptoms after stopping finasteride treatment, suggesting lingering neuropsychiatric effects.

This review highlights the need for a deeper understanding of 5alpha-reductases and neuroactive steroids to reduce potential adverse effects of 5alpha-reductase inhibitors used for conditions like benign prostatic hyperplasia and androgenic alopecia, but reports no new clinical results.

This study found that cortexolone 17α-propionate showed strong topical antiandrogenic activity, outperforming progesterone and several known antiandrogens, but lacked systemic antiandrogenic effects in animal models.

This review discusses the potential of DHEAS and testosterone treatments to increase muscle mass in older men with sarcopenia, while effects on muscle function and physical performance remain unclear, and calls for further research on optimized approaches.

Steroid hormones can help treat aging issues and improve health in elderly people.

This study found that testosterone applied to aging skin modestly reduced wrinkles and improved microscopic skin architecture, while ethinyl estradiol showed no effect and corticosteroids worsened skin aging changes.

This study found that both finasteride and a new steroidal compound, PM-9, competitively inhibit the 5α-reductase enzyme in Penicillium crustosum broth.

This article reviews the potential male equivalent of polycystic ovarian syndrome, focusing on hormonal alterations and premature androgenic alopecia, but reports no new clinical findings; the authors highlight the need for further studies on adrenal steroids and other factors.

In this study, 50 mg/day of DHEA supplementation in postmenopausal women did not significantly improve sexual function compared to a placebo over 26 weeks.

This review discusses the role of skeletal muscle in synthesizing bioactive androgens, highlighting that intramuscular androgens may influence muscle via intracrine action, but their precise function remains unclear.

This study reported that treatment with cyproterone acetate alone and then with incremental estrogen doses induced mild feminizing effects in late-pubertal trans-girls, with further feminization observed after adding estrogen.

In this case report, a man developed loss of libido, decreased hair growth, and gynecomastia after using an estrogen-containing hair tincture, but symptoms resolved and hormone levels normalized after he stopped using it.

This study demonstrated that steroidal carbamates 7–10 altered mRNA expression related to lipid metabolism in hamster flank organs and inhibited 5α-reductase activity without binding to the progesterone receptor.

This chapter reviews the biosynthesis, mechanism of action, and therapeutic effects of testosterone and related androgens, but reports no new research findings.

This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.

In this study, an ultra-low dose combination of estradiol and dydrogesterone significantly reduced hot flushes and improved health-related quality of life among a multi-ethnic population of postmenopausal women, with no notable difference in serious adverse events compared to placebo.

This study reports that testosterone requires conversion to DHT and estradiol for its various actions on external genitalia and bone, influencing lean mass, muscle size, strength, and body fat in hypogonadal males.

In this study, osthenol was identified as a highly potent inhibitor of 5alpha-reductase type I in LNCaP cells, significantly outperforming finasteride.

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.

This study reports that using molecular docking methods, beta-sitosterol and stigmasterol from Serenoa repens were identified as potential natural inhibitors of the 5AR1 enzyme, which could serve as novel treatments for androgenetic alopecia based on their inhibitory action observed in a laboratory setting.

In this study, patients with varying severities of acne, seborrhoea, and hirsutism responded differently to Cyproteronacetate and Ethinyloestradiol treatment, with improvement rates dependent on symptom severity and treatment duration.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

This study found that male 5α-reductase 2 knockout mice showed deficits in social dominance behaviors and reduced dopamine receptor binding in a brain region related to social ranking.

This study found no correlation between clinical stages of androgenetic alopecia and serum DHEA-S levels in men, contrasting with previous studies suggesting elevated levels.

This article reviews the limited evidence on testosterone therapy for premenopausal women and notes a lack of long-term safety and effectiveness data for this population.

This review summarizes the latest evidence on testosterone, detailing its clinical indications, diagnostic tests, and impacts on various male organs, while also noting its association with aging, metabolic disorders, and increased mortality risk due to androgen deficiency.

This case report describes a postmenopausal woman who experienced facial erythema, acne, and hirsutism due to excess androgen and estrogen levels.

In this study, high-dose dutasteride significantly reduced several core symptoms of PMDD compared to placebo, supporting the role of neurosteroids in this condition.