Iatrogenic Androgen And Estrogen Excess In A Postmenopausal Woman Presenting With Facial Erythema, Acne, And Hirsutism

In 2009, a case report described a 65-year-old postmenopausal woman who developed facial erythema, acne, and hirsutism due to excessive androgen and estrogen levels caused by monthly injections of Disemone® (testosterone enanthate and estradiol valerate) for insomnia over a period of 5 years. Her hormone levels were three times higher than the normal upper limit. Upon discontinuing the hormone therapy and initiating treatment with adapalene, metronidazole, and azatadine, her hormone levels decreased, and her symptoms improved within four months. The case underscored the need for cautious use of hormone replacement therapy in older patients, thorough medical and drug history assessments, and consideration of nonhormonal treatments for managing hormone withdrawal symptoms.