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    Did you mean Lysyl Hydroxylase?
    Glossary Lysyl Hydroxylase

    enzyme modifying lysine in collagen for tissue strength

    Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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    Research 30 of 186

    1. Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis Matrix Biology · 2005 · 38 citations
    2. Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. Journal of Biological Chemistry · 1987 · 63 citations
    3. Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note Journal of Pharmacology and Experimental Therapeutics · 2020 · 2 citations
    4. Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity KSBB Journal · 2012
    5. Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987 Clinical and Experimental Dermatology · 1989
    6. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009 · 37 citations
    7. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987 · 19 citations
    8. Inflammatory perifollicular fibrosis and alopecia International Journal of Dermatology · 1998 · 10 citations
    9. Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis Biomacromolecules · 2024 · 6 citations
    10. Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp Clinics in Dermatology · 1988 · 5 citations
    11. The Effect of the Drug Minoxidil on Hair Growth 1988 · 3 citations
    12. Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment. bioRxiv (Cold Spring Harbor Laboratory) · 2024
    13. Acne Scar Management: Minoxidil as a Promising Approach or a Mirage? International journal of biomedicine · 2023
    14. Chelators Depigment and Inorease Elasticity of Mink Skin Acta Agriculturae Scandinavica · 1987 · 2 citations
    15. Chapter 20. Pathogenesis and Treatment of Alopecias Annual Reports in Medicinal Chemistry · 1989 · 8 citations
    16. Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection (Mesotherapy) for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-month Randomized Trial 2010 · 1 citations
    17. Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model Tissue Engineering and Regenerative Medicine · 2024 · 9 citations
    18. Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion Journal of Human Immunity · 2025 · 1 citations
    19. Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome Journal of Clinical Investigation · 2022 · 9 citations
    20. Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts Molecular & cellular proteomics · 2019 · 9 citations
    21. A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration Archives of Dermatological Research · 2011 · 16 citations
    22. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016 · 42 citations
    23. ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 Frontiers in Physiology · 2018 · 17 citations
    24. HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth Skin Pharmacology and Physiology · 2020 · 6 citations
    25. Estrogens and the skin Climacteric · 2005 · 137 citations
    26. The effect of menopause on the skin and other connective tissues Gynecological Endocrinology · 2011 · 44 citations
    27. Mammalian Fetal Organ Regeneration 2005 · 32 citations
    28. Hormone replacement therapy and the skin Maturitas · 2000 · 138 citations
    29. Expanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral and sublingual formulations Frontiers in Pharmacology · 2026
    30. Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome Gynecological Endocrinology · 2009 · 29 citations