41 citations
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March 2007 in “Journal of dermatological science” This study found that oral administration of l-cystine with vitamin B6 effectively prevents environmental cigarette smoke-induced alopecia in mice by reducing hair bulb cell apoptosis.
7 citations
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March 2011 in “Hormone and Metabolic Research” This study found that in PCOS patients, variations in the lipin 1 gene, particularly the intron 1 SNP, may protect against insulin resistance and glucose intolerance, highlighting a potential genetic factor in the disorder's cardiometabolic complications.
2 citations
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August 2018 in “Korean Journal of Plant Resources” This study found that oregonin, isolated from Alnus japonica, demonstrated strong antioxidant activity and apoptosis modulation in hair follicle cells, suggesting its potential as a natural ingredient for preventing hair loss in cosmetic products.
April 2023 in “Journal of Investigative Dermatology” In this study, the combination of two compounds activated AMPK levels in skin cells, reducing oxidative damage and improving energy production, which may support faster recovery and repair in aging skin.
January 2013 in “Anti-infection Pharmacy” This review discusses the pharmacological and dermatological uses of Ligustri Lucidi Fructus and its components, such as anti-inflammation, anti-allergy, anti-dermatotumor effects, and hair growth promotion, but reports no new clinical results.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the potential of ridge gourd (Luffa acutangula) in promoting healthy hair growth due to its nutrients and antioxidants, with suggestions of benefits such as follicle strengthening and delaying graying, though it calls for more clinical studies to verify these effects.
6 citations
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May 2022 in “Journal of Cosmetic Dermatology” In this study, Lagerstroemia indica extract was found to significantly promote hair growth and prevent hair loss in human trials, likely through the regulation of specific signaling pathways, indicating its potential as a cosmetic treatment for hair loss prevention.
14 citations
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September 1983 in “Acta Dermato Venereologica” This study found that daily topical application of citral increased sebaceous gland lobules and cell hyperplasia in male rats after three months.
May 2008 in “The International Conference on Mathematics and Engineering Physics” This study reports that combining low level laser treatment with liposome-delivered methylene blue may effectively target sebaceous glands in mice, with efficacy influenced by laser timing and drug absorption.
October 2024 in “Media Farmasi” In this in vitro study, researchers found that a combination of soursop leaf extract and doxorubicin moderately enhanced the anti-cancer effect against MCF-7 breast cancer cells, but they did not report on reducing doxorubicin's side effects.
May 2023 in “Pharmaceuticals” In this in silico study, researchers analyzed nonsynonymous SNPs in the LIPH gene linked to hypotrichosis and identified three potentially harmful variants (W108R, C246S, and H248N) out of 215 total, using sequence- and architecture-based bioinformatics techniques to differentiate between harmful and benign SNPs.
11 citations
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June 2012 in “Archives of Dermatological Research” This study demonstrated that high doses of L-cystine and vitamin B6 effectively prevent doxorubicin-induced hair loss in mice.
July 2024 in “Journal of Investigative Dermatology” Patients with cutaneous lupus erythematosus have a higher risk of skin cancer and other cancers.
26 citations
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January 2016 in “Annals of Dermatology” This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.
4 citations
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September 2025 in “International Journal of Molecular Sciences” This review discusses the dermatological applications and potential health benefits of Epigallocatechin-gallate (EGCG) from green tea, but provides no new clinical findings.
59 citations
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January 2015 in “Nanoscale” In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.
43 citations
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September 2021 in “Nutrients” This review discusses the vast potential uses of persimmon beyond its dietary benefits, including applications in sustainability and new product development, but reports no new clinical outcomes.
83 citations
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October 2012 in “International Journal of Oncology” In this in vitro study, wedelolactone induced selective apoptosis in prostate cancer cells by inhibiting 5-Lox activity, suggesting it may have potential as a treatment for prostate cancer.
July 2023 in “Journal of the Mexican chemical society” This study found that Hibiscus rosa-sinensis dried leaves extract displayed the strongest pancreatic lipase inhibitory activity among 37 tested plant extracts, showing potential as an anti-obesity agent with effects comparable to the pharmaceutical drug orlistat in reducing plasma triacylglycerol levels in rats.
January 2024 in “Journal of Medicinal Food” This study found that Nephelium lappaceum extract restored hair growth more effectively than finasteride in mice with testosterone-inhibited hair growth, suggesting its potential as a nutraceutical for hair growth.
April 2026 in “Journal of Microbiology Biotechnology and Food Sciences” This study found that Carthamus caeruleus (L.) leaf extracts possess higher antioxidant and antibacterial activities compared to rhizome extracts, and are rich in phenolic and flavonoid compounds, suggesting potential use as a natural therapeutic agent.
October 2024 in “Current Issues in Molecular Biology” In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.
2 citations
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February 2004 in “Biopolymers” This study found that 4-(4-Phenoxybenzoyl)benzoic acid derivatives may act as antioxidants by scavenging certain reactive oxygen species but exhibit prooxidant behavior under specific conditions.
This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.
1 citations
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January 2014 This study found that Crataegus pinnatifida extract promoted hair growth in mice by inducing the anagen phase, potentially through activating signaling pathways that enhance cell survival.
8 citations
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February 2025 in “Cell Systems” This study developed a genetic toolbox to engineer Cutibacterium acnes for dermal applications, successfully creating a strain that secretes antioxidants to reduce oxidative stress in a UV stress model.
1 citations
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January 2021 in “Elsevier eBooks” This study found that olive and olive oil may significantly reduce cardiovascular disease risk, cholesterol, and blood pressure, while offering antioxidant protection through bioactive metabolites like oleuropein.
43 citations
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August 2016 in “International Journal of Nanomedicine” This study found that a eupafolin nanoparticle delivery system improved water solubility and skin penetration, enhancing its antioxidant and anti-inflammatory effects against particulate matter-induced stress in skin cells.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.
April 2017 in “Journal of Investigative Dermatology” This study found that a single dose of TRP significantly reduced the number of UV-B-induced actinic keratosis lesions in a mouse model and was associated with improved skin histology and minimal side effects.