Modulative Effect of Human Hair Dermal Papilla Cell Apoptosis by Oregonin from the Branches of Alnus Japonica

The study investigated the potential of oregonin, a compound isolated from the branches of Alnus japonica, as a natural agent for preventing hair loss. Oregonin demonstrated strong antioxidant properties by effectively scavenging reactive oxygen species, which are linked to hair follicle cell apoptosis. The research suggested that oregonin could modulate the apoptosis of dermal papilla cells, which are crucial for hair growth, thereby reducing oxidative stress-induced cell death. This indicated that Alnus japonica extracts, containing oregonin, could be developed as a natural hair loss prevention and hair growth-promoting material for cosmetic applications.