Sebaceous Glands Changes Following Topical Application of Citral

    September 1983 in “ Acta Dermato Venereologica ”
    A. Abramovici, Robert Christian Wolf, Miriam Sandbank
    TLDR Citral increases sebaceous gland activity in male rats.
    The study investigated the effects of citral, a flavor cosmetic constituent, on male rat skin. Over 3 months, daily topical application of a 15.4% citral solution led to an increase in the number of sebaceous gland lobules and hyperplasia of sebaceous cells. The suggested mechanism for this hyperplasia was the activation of testosterone 5 alpha-reductase, which induces the formation of dihydrotestosterone, a mediator of sebaceous gland activity.
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