Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study identified the rough coat mutation in mice, but found that LOXL is not the causal gene, although its downregulation might contribute to related phenotypic changes.

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

In this study, a transgenic mouse model was used to demonstrate that targeted cell loss in different tissues led to varying degrees of regenerative outcomes, including reversible impaired glucose tolerance, irreversible hair loss, and permanent moderate deafness.

This study successfully created a mouse model with conditional knockout of the p75 neurotrophin receptor gene in epidermis cells, with no significant changes in skin histomorphology observed.

This study found that high-resolution tusk isotope profiles from an African elephant can serve as a proxy for the seasonality of diet and precipitation, helping to reconstruct vegetation and climate in modern and fossil ecosystems.

This study observed that PCR-based genotyping for cre-loxP mice can lead to errors due to cre-mediated recombination in non-target tissues like tails, affecting the detection of lox alleles.

This review discusses the experimental targets of fetal wound healing and evaluates existing therapies for scarless healing in adult skin, but reports no new research findings.

This study identified several DPC-specific proteins, including ITGB1, IGFBP3, and THBS1, as potential biomarkers for hair growth modulation through proteomic and network analysis.

This study found that deleting FoxN1 in specific thymic epithelial cells disrupted the 3D thymic structure and led to age-dependent formation of 2D epithelial cysts, highlighting FoxN1's critical role in thymic morphogenesis.

This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.

This study found that porcine-placenta-extract-loaded nanoformulated serum improved skin hydration and promoted hair growth, as well as reduced intracellular ROS and inflammation without cytotoxicity in human subjects.

This study reported that a Megsin-Cre transgene enables genetic manipulation primarily in skin, forestomach, and esophagus tissues, offering a new tool for studying development and diseases in these areas.

This study reported that in degenerative alopecia, Zn²⁺/Cu²⁺-dependent proteases are downregulated and destabilized, and a specially developed microneedle patch reactivated these enzymes, reduced senescence, and enhanced hair regeneration in an animal model.

In this in vitro study, wedelolactone induced selective apoptosis in prostate cancer cells by inhibiting 5-Lox activity, suggesting it may have potential as a treatment for prostate cancer.

In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.

This study describes a method for labeling and tracking hair follicle stem cells in mouse skin using a Cre/lox recombination system with tamoxifen, providing insights into stem cell behavior and contribution to tissue regeneration.

This study observed that mice with a whole-body deficiency of Cystathionine-β-synthase developed severe hyperhomocysteinemia and related mild symptoms without increased mortality, indicating HHCy may not directly cause end organ damage.

This study identified a long noncoding RNA, LOXL1-AS1, with potential diagnostic significance in androgenic alopecia, which may regulate TP53 expression by targeting hsa-miR-5193 within a ceRNA network.

This study presents two new mouse models using the CreER T2-loxP system to target and study melanocytic cells, with implications for melanoma research.

In this study, bovine milk-derived oligosaccharides were found to increase sebocyte proliferation, lipid content, and inflammatory mediator synthesis through the mTORC1 pathway, potentially contributing to milk-based inflammation in sebocytes.

This study found that knockout mice lacking intestinal hephaestin are smaller and anemic compared to wild-type, suggesting other mechanisms may compensate for iron absorption.

This study reports that eliminating both Trp53 and Rb genes in mouse epidermis accelerates aggressive squamous cell carcinoma development due to early activation of the epidermal growth factor receptor/Akt pathway.

The study concluded that fatty acid transport protein 4 in epidermal keratinocytes is crucial for maintaining normal skin structure, as its deficiency led to hyperkeratosis and epidermal barrier disruption in mice.

This study found that multiple ion channel modulators, used here at clinical concentrations, increased intracellular calcium release in prostate and breast cancer cell lines.

Some patients with Alopecia Areata experience itch due to immune cells and enzymes that cause itching.

Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.

The researchers reported that introduction of SOX9 in ischemic heart tissues is linked to cardiac fibrosis, marking it as a potential target for future therapeutic strategies.

Different medications can cause serious side effects in some people.

This study reported that women with PCOS had higher levels of depression, anxiety, and perceived stress compared to those without PCOS, with stress potentially mediating these associations.

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.