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Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Aging causes skin stem cells to work less effectively.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Human hair follicle stem cells can turn into multiple cell types but lose some of this ability after being grown in the lab for a long time.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

Dermal papilla cells help wounds heal better and can potentially grow new hair.

Msx2 and Foxn1 are both crucial for hair growth and health.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.