72 citations
,
June 2001 in “Journal of Investigative Dermatology” This study suggests that S100A4 and S100A6 proteins may play key roles in activating stem cells for hair follicle regeneration in mice.
69 citations
,
December 2016 in “Facial plastic surgery” This review discusses the anatomical and histological characteristics of facial fat compartments and reports no new clinical results, emphasizing a need for further research on their role in facial aging.
67 citations
,
July 1985 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that males have significantly longer hair on their thighs compared to females, mainly due to a longer anagen phase and a greater rate of growth.
66 citations
,
March 2009 in “British journal of surgery” This review discusses hidradenitis suppurativa's pathogenesis, including its inflammatory nature and the role of smoking as a triggering factor, but reports no new clinical results.
62 citations
,
July 2018 in “Lasers in Medical Science” In this review, the researchers highlight LED therapy as an emerging and safe treatment for skin inflammatory conditions, aging, and hair growth disorders, noting its integration into dermatological practice but emphasizing the need for more controlled studies to confirm its efficacy.
61 citations
,
January 2018 in “Cosmetics” This review highlights the potential of coffee silverskin's bioactive compounds in combating skin aging and related conditions, suggesting it as a promising natural ingredient for cosmetics due to its antioxidant, anti-inflammatory, and anti-aging properties.
60 citations
,
January 2023 in “Biogerontology” This review examines testosterone's role in male health and aging but reports no new clinical results; the authors highlight the need for further research on optimal testosterone levels to prevent age-related conditions.
60 citations
,
April 2012 in “Physiology” This article explores how extrafollicular environments and stem cell configurations influence hair and feather regeneration but provides no new experimental results.
59 citations
,
June 2023 in “Nature Aging” This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.
59 citations
,
September 2007 in “Biochemical and Biophysical Research Communications” This study found that a gain-of-function mutation in the TRPV3 channel leads to altered hair development in DS-Nh mice by affecting the anagen and telogen phases, highlighting TRPV3's role in hair growth regulation.
59 citations
,
January 2005 in “Endocrine Journal” This study found that sex steroid hormone receptors are largely maintained during the transformation of skin appendages to neoplasms, except for androgen and estrogen receptors in sweat and sebaceous gland tumors.
56 citations
,
May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
54 citations
,
November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology” This chapter reviews keratins in skin epithelia, including their roles in cellular function and disease, and reports no new experimental results.
53 citations
,
November 2006 in “Journal of Endocrinology” This study found that prolactin plays a direct role in regulating the timing of hair growth cycles in mice by affecting the skin, rather than through other endocrine factors.
52 citations
,
January 2020 in “Scientific Reports” This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.
52 citations
,
February 2006 in “Current pharmaceutical design” This review discusses the use of 5α-reductase inhibitors in treating benign prostatic hyperplasia, highlighting their long-term effectiveness and benefits when combined with α1-adrenergic antagonists; it reports no new clinical results.
51 citations
,
February 2009 in “Journal of dermatological science” In this study, β-catenin overexpression in human hair outer root sheath cells increased the expression of Pitx2, which activated the follicular differentiation pathway, suggesting Pitx2's potential role as a modulator in hair growth control.
51 citations
,
January 2001 in “Biological & Pharmaceutical Bulletin” This study found that the aqueous ethanol extract of Myricae Cortex demonstrated in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic effects in mouse and hamster models.
51 citations
,
January 1989 in “Journal of Investigative Dermatology” This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.
47 citations
,
September 2023 in “Pharmacological Reports” In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.
47 citations
,
March 2022 in “Frontiers in cellular and infection microbiology” This review discusses the role of the skin microbiome in the pathogenesis of various skin disorders, such as atopic dermatitis and psoriasis, and reports no new clinical findings; it emphasizes potential therapeutic implications.
47 citations
,
March 2019 in “Journal of immunology research” This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.
47 citations
,
June 2015 in “Medicines” This review examines the use and efficacy of Panax ginseng in various clinical settings, noting that clinical trial outcomes vary widely based on study conditions and ginseng types; no new results are reported.
46 citations
,
May 2012 in “Molecular and Cellular Endocrinology” In this study, higher expression levels of aromatase and steroidogenic acute regulatory protein were correlated with increased estrogen synthesis and fewer hair follicles in human skin, suggesting a link to elastic fiber formation and hair growth.
46 citations
,
January 2009 in “Textile Research Journal” This study presents a DNA-analytical method that can reliably identify and differentiate cashmere, fine wool, yak, and camel hair fibers in both untreated and processed samples.
46 citations
,
May 1986 in “Seminars in Reproductive Medicine” Testosterone and dihydrotestosterone affect hair growth, and new techniques like the folliculogram help study it, but fully understanding hair growth is still complex.
44 citations
,
June 2009 in “Biomaterials” In this study, fibronectin coating on a low-adhesive substratum increased cell aggregation, growth, and motility, enhancing the formation of hair follicle dermal papilla spheroids.
43 citations
,
February 2020 in “Clinica chimica acta” This review discusses the role of phytochemical nanoparticles in cervical cancer therapy and reports no new clinical results; the authors highlight their potential advantages over conventional chemotherapy.
43 citations
,
August 2016 in “Scientific Reports” This animal study found that Cinnamomi cortex water extract reduced prostate weight and improved histological changes in a benign prostatic hyperplasia model, suggesting potential as a treatment.
43 citations
,
June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.