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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.

Men with Type 2 Diabetes have lower DHT levels, which may affect fertility and lipid profiles.

DHT may increase the risk of heart disease and death in elderly men.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Testosterone therapy may improve mood, well-being, and sexual function in premenopausal women, but more research is needed on its long-term safety and effectiveness.

Testosterone therapy can improve sexual satisfaction and mood in surgically menopausal women when used with estrogen, but its long-term safety and effects on naturally menopausal and premenopausal women are unclear.

Testosterone's muscle-building effects do not require its conversion to DHT.

Testosterone improves mood and thinking skills; finasteride has no effect.

Men with less sun-sensitive skin have lower PSA levels, while men with more sun-sensitive skin have higher PSA levels.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Testosterone is crucial for development, growth, and various body functions in mammals.

Vitamin D may help reduce antibody levels in men with autoimmune thyroiditis and early-onset androgenic alopecia, but has no significant impact on thyroid function.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

Finasteride may effectively treat hair loss in Klinefelter Syndrome patients.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.

Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

Some common medications can harm male fertility, but many effects can be reversed.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Men with benign prostatic hyperplasia are more likely to have metabolic syndrome than those without it.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.