Associations Between Serum Dihydrotestosterone Levels, Lipid Parameters, and Anthropometric Measurements in Male Patients with Type 2 Diabetes Mellitus

July 2022 in “ International Journal of Health Sciences (IJHS) (En línea) ”

Sanket Jheetay, Ravinder Garg, Ritu Adhana, Jayballabh Kumar, Himani Muniyal

dihydrotestosterone DHT lipid parameters Type 2 Diabetes Mellitus serum DHT levels

TLDR Men with Type 2 Diabetes have lower DHT levels, which may affect fertility and lipid profiles.

The study investigated the relationship between serum dihydrotestosterone (DHT) levels, lipid parameters, and anthropometric measurements in male patients with Type 2 Diabetes Mellitus. Conducted at Teerthanker Mahaveer Medical College and Research Centre and Santosh Medical College, it included 210 participants (105 diabetics and 105 controls). Results showed that serum DHT levels were significantly lower in diabetics compared to healthy controls (230.66 ± 182.02 pg/ml vs 439.26 ± 257.87 pg/ml, p=0.001), with 90% of diabetics having subnormal DHT levels compared to 10% of controls. This suggests a strong association between Type 2 Diabetes and reduced DHT levels, potentially impacting male fertility and lipid profiles.

View this study on sciencescholar.us →

Discuss this study in the Community →

Related Community Posts Join

6 / 134 results

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 4 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 57 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 2 months ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

Similar Research

5 / 1000+ results

The Differences Between Aromatizable And Non-Aromatizable Androgens In Relation To Body Composition And Metabolic Syndrome Risk Factors In Men

research The Differences Between Aromatizable And Non-Aromatizable Androgens In Relation To Body Composition And Metabolic Syndrome Risk Factors In Men

8 citations, March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

research Serum Concentrations of Dihydrotestosterone Are Associated With Symptoms of Hypogonadism in Biochemically Eugonadal Men

5 citations, April 2021 in “Journal of Endocrinological Investigation”

Higher DHT levels are linked to fewer hypogonadism symptoms in men with normal testosterone levels.

The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver

research The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver

6 citations, January 2021 in “International Journal of Molecular Sciences”

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

research Relationship Between Steroid Hormones and Metabolic Profile in Women With Polycystic Ovary Syndrome

13 citations, March 2019 in “Physiological Research”

Overweight women with PCOS have higher levels of certain hormones that could indicate a higher risk of heart and metabolic problems.

research Hair Loss in Women: Comprehensive Overview and Treatment Options

81 citations, March 2009 in “Seminars in Cutaneous Medicine and Surgery”

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.