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Studying rare genetic disorders can help us understand and treat common diseases better.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

A mutation in the IKZF1 gene causes immune system overactivity, linked to autoimmune diseases like lupus.

DAVID syndrome is a condition with immune system and hormone deficiencies, needing early diagnosis to avoid serious complications.

DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

A mutation in the HR gene causes a rare form of irreversible hair loss in two Kashmiri families. Whole exome sequencing is effective for finding such mutations.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

Men with Kennedy disease have less chance of hair loss.

A new mutation in the AGPAT2 gene causes severe fat tissue loss and related health issues by reducing the protein's levels.

JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.

Biotin and acetazolamide improved hair and nail growth, mental function, and reduced headaches in a child with autism.

A 14-year-old girl with severe hair loss regrew her hair using upadacitinib.

Removing Dicer from pigment cells in newborn mice causes early hair graying and changes in cell migration molecules.

Cetaceans lost hair due to changes in the Hr and FGF5 genes.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

Topical treatments led to hair regrowth in a man with linear morphea.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.

Dutasteride is more efficient than finasteride, but individual results vary.

Bleaching hair damages protein structure, especially keratin, leading to weakened hair.

Minoxidil effectively treats female pattern hair loss.

MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Whale genes show changes that help them live in water, like less hair and better flippers.

Researchers found a genetic region that influences the number of coat layers in dogs.

Three new types of a skin blistering disease were found, caused by specific gene mutations.