April 2025 in “Journal of Diabetes & Metabolic Disorders” This study found that linc-PINT expression was significantly decreased in patients with atrial fibrillation compared to healthy controls, while several TGF-β signaling genes were increased, suggesting a potential role in heart arrhythmias' pathogenesis.
140 citations
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February 2014 in “Neuron” This study found that the opioid system, particularly via the delta opioid receptor, broadly regulates cutaneous mechanosensation, including touch, and suggests targeting this receptor could alleviate injury-induced mechanical hypersensitivity.
April 2023 in “Journal of Investigative Dermatology” In this study, low-dose spironolactone reduced the severity of female pattern hair loss in a small group of women without causing significant side effects, suggesting it may be an effective and well-tolerated treatment option.
51 citations
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April 1982 in “Lancet” This study found that multiple treatment regimens for refractory hypertension were effective in controlling blood pressure in most patients, with diazoxide being the most effective but least tolerable option.
January 2014 in “Jaypee Brothers Medical Publishers (P) Ltd. eBooks” Bimatoprost may help with hair loss.
September 2025 in “Journal of the American Academy of Dermatology” Low-dose oral minoxidil does not significantly affect blood pressure in patients with hair loss and hypertension.
15 citations
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April 2020 in “Journal of The American Academy of Dermatology” This article notes the lack of physician-reported outcome studies supporting the efficacy of off-label spironolactone in treating female pattern hair loss, despite its common prescription alongside FDA-approved topical minoxidil.
5 citations
,
July 2020 in “JAMA Dermatology” Minoxidil solution applied twice daily improved hair growth in patients with Woolly Hair/Hypotrichosis due to LIPH gene issues, with mild side effects.
19 citations
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May 2018 in “Molecular Medicine Reports” This study found that miR-339-5p negatively regulates loureirin A-induced differentiation of hair follicle stem cells, potentially impacting skin repair and regeneration by inhibiting the Wnt/β-catenin signaling pathway.
43 citations
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May 1978 in “JAMA” Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.
1 citations
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January 1987 in “Journal of The American Academy of Dermatology” The patient's hair loss was likely not caused by beta blockers but possibly by stress or other factors.
50 citations
,
September 1975 in “American Heart Journal” Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.
35 citations
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December 1979 in “Naunyn-schmiedebergs Archives of Pharmacology” These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
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48 citations
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January 2020 in “Cochrane Database of Systematic Reviews” This study found that serlopitant may reduce pruritus intensity compared to placebo in patients with chronic pruritus of unknown origin, though evidence is of low certainty and effects on other outcomes are unclear.
October 2015 in “Elsevier eBooks” Pramipexole can cause side effects like dizziness, sleepiness, hallucinations, and low blood pressure, and it's important to educate patients and keep doses low.
3 citations
,
March 2012 in “Arab Journal of Urology” This study found that cromakalim and pinacidil significantly inhibited porcine detrusor muscle contractions, suggesting these ATP-sensitive potassium channel openers may have potential in treating certain bladder diseases.
27 citations
,
April 1992 in “Biochemical Journal” Minoxidil reduces lysine hydroxylase in skin cells.
18 citations
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July 1975 in “Clinical Pharmacology & Therapeutics” Oral minoxidil effectively controls blood pressure quickly and safely.
1 citations
,
September 2023 in “Journal of The American Academy of Dermatology” This abstract reviews the use of low dose oral minoxidil as a monotherapy for hair loss and reports no new clinical data.
23 citations
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November 1986 in “Pediatrics” Minoxidil, when used with a diuretic and β-blocking agent, can safely lower blood pressure in most children with severe hypertension due to kidney disease, with minimal side effects.
August 2024 in “Journal of Personalized Medicine” In this study using a rabbit model, higher incidences of intraoperative floppy iris syndrome were observed in animals given the α-blocker tamsulosin, suggesting a potential association with increased iris billowing during eye surgery.
July 1987 in “Reactions (Auckland)” Oral minoxidil may slow male pattern baldness and cause body hair growth, but hair loss can happen after stopping it.
April 2014 in “Emergency Medicine News” This case report highlights the diagnostic challenges of thyroid storm, emphasizing the importance of a thorough history and review of systems to differentiate it from other conditions.
May 2025 in “International Journal of Trichology” This retrospective study in a tertiary hair clinic concluded that routine monitoring of heart rate, weight, liver, and kidney function is not necessary for asymptomatic patients with normal baseline values undergoing low-dose oral minoxidil treatment, although monitoring is advised for those with preexisting renal impairment.
52 citations
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July 1998 in “Urology” This study found that liarozole is more effective than cyproterone acetate for improving PSA response and survival in metastatic prostate cancer after first-line endocrine therapy, while maintaining quality of life.
36 citations
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May 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.
September 2022 in “Journal of The American Academy of Dermatology” This study examined the incidence of hyperkalemia in women over 65 with female pattern hair loss and spironolactone use, but the findings on risk remain unclear.
September 2024 in “Journal of Cosmetic Dermatology” This study examined the FDA Adverse Event Reporting System database and found significant associations between low-dose oral minoxidil use and adverse events like pericardial effusion, highlighting the need for caution and recommending the use of the lowest effective dose until more safety data are available.
April 2010 in “PubMed Central” This abstract discusses the FDA approval of Latisse (bimatoprost) for increasing eyelash growth in patients with eyelash hypotrichosis and highlights its efficacy while noting unresolved effectiveness in certain conditions and potential side effects.