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A boy with toxic shock syndrome had severe heart rhythm problems but recovered with treatment.

This review summarizes how genetic studies using conditional β-catenin loss- and gain-of-function mice have advanced understanding of canonical Wnt signaling's role in embryonic development, adult stem cell maintenance, and cancer modeling.

Ets2 gene is crucial for placental development in mice.

This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.

This study reports that overexpression of activin in transgenic mice enhances granulation tissue formation during wound healing, highlighting a novel role for activin in cutaneous repair processes.

This study suggests that the protease HAT-L4 plays a significant role in maintaining epidermal barrier function to prevent body fluid loss, as its absence in mice led to increased fluid loss and higher mortality.

This study identified a novel homozygous EDNRA variant linked to Oro-Oto-Cardiac Syndrome and showed that EDNRA signaling is essential for normal craniofacial and cardiovascular development.

In this review, researchers discussed recent insights into caspases, enzymes initially associated with cell death and inflammation, revealing their broader roles in cell proliferation, migration, and differentiation, and highlighting the importance of caspase knock-out mice for understanding their implications in diseases.

This study suggests that the use of 5α-reductase inhibitors in men may be associated with macular abnormalities, characterized by cystoid changes and foveal cavitation, potentially progressing to more severe defects.

This study found that young women with PCOS exhibited altered white matter microstructure and reduced cognitive performance compared to matched controls.

This study reported that knocking out the HR gene in pigs using CRISPR/Cas9 led to hairless eyelids and abnormalities in the thymus and peripheral blood, suggesting pigs as a model for human HR-related hair disorders.

This study found that gonadal dysfunction is very common in premenopausal women with acromegaly and may be caused by hyperprolactinemia, GH/IGF-I excess, or tumor effects.

This review discusses current treatment options for liver hydatidosis, noting the potential benefits and limitations of chemotherapy and highlighting the need for more clinical trials to prevent recurrent disease; it reports no new findings.

This study highlights the potential increased frequency of advanced liver disease in obese PCOS patients with NAFLD and underscores the importance of lifestyle modifications as initial treatment.

This study reported that almost 25% of women with PCOS were diagnosed with NAFLD, and 32.7% to 44.6% had metabolic syndrome, with higher prevalence in those with both conditions.

This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.

This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.

This study found that the CXXC5 protein is overexpressed in diabetic foot ulcer tissues, suppressing wound healing, and that the small molecule KY19334 accelerated healing in diabetic mice by activating the Wnt/β-catenin pathway.

This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.

In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.

This study observed no teratogenic effects of oral decongestants and surprisingly favorable neonatal outcomes in Swedish women who used them during pregnancy.

This study observed that lifestyle modifications resulting in weight loss improved menstrual irregularity and hormonal balance among infertile obese women with polycystic ovary syndrome, although changes in total testosterone and estrone were not significant.

This study found that in obese mice, local antimicrobial activity is reduced due to a loss of adipogenic stem cells and an increase in mature adipocytes, leading to higher susceptibility to skin infections.

This study found that knock-down of keratin 15 in various cell lines affected cell spreading, morphology, migration, differentiation, and proliferation, suggesting its role in maintaining the stem cell nature of keratinocytes.

This review discusses the impact of hormones on female sexual function and dysfunction, highlighting the complexity and gaps in basic research, and reports no new clinical findings.

This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.

This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

This review addresses the role of skin-resident adult stem/progenitor cells in skin homeostasis, disease, and cancer development, and reports no new research results.

This review discusses how recent advances in live imaging have revealed the dynamic and adaptable nature of stem cells during various biological processes, and reports no clinical results.