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Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Overexpression of HDGF in melanocytes does not cause cancer.

Finasteride may cause breast enlargement, low testosterone a risk factor.

Isotretinoin is a preferred treatment for severe acne, often leading to long-term improvement, but requires careful monitoring due to potential side effects.

Transplant patients face higher skin cancer risks due to immunosuppressive therapy, requiring careful skin health monitoring.

CHOP chemotherapy causes many side effects but is generally well tolerated.

Posaconazole is a promising new treatment for toenail fungus.

Androstenedione, a hormone supplement, doesn't improve muscle or performance and can cause harmful side effects.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Transplant success has improved with better immunosuppressive drugs and donor matching.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Cetuximab can cause excessive eyelash growth.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.

Certain drugs that block specific enzymes can help treat prostate diseases.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.