November 2025 in “Journal of Investigative Dermatology” Light skin shows more inflammation from sun exposure than dark skin.
August 2018 in “Journal of Investigative Dermatology” This study found that combining optical clearing methods with light-sheet fluorescence microscopy allows detailed 3D visualization of normal and pathological human skin biopsies, revealing differences in epidermal thickness and volume.
195 citations
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January 2008 in “Photochemistry and Photobiology” This review discusses the effects of visible light on human skin, highlighting its role in pigmentation, thermal damage, and the treatment of several skin conditions, while noting limited sunscreen protection against it; no new clinical results are reported.
3 citations
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April 2025 in “Advanced Healthcare Materials” In this study, researchers developed hyaluronic acid derivatives functionalized with nitric oxide photodonors for light-activated skin treatments, finding that the compounds released NO under blue light and enhanced keratinocyte proliferation and migration, suggesting potential for therapeutic use.
April 2024 in “International journal of molecular sciences” This narrative review discusses the promising role of photobiomodulation in dermatology, emphasizing its non-invasive nature and potential benefits, but acknowledges the need for further research to establish standard protocols.
April 2024 in “Lasers in medical science” This study found that near-infrared LED therapy enhanced ATP synthesis, reduced reactive oxygen species, and promoted collagen production and hair growth more effectively than white LEDs in human skin cells and a photoaging mouse model.
May 2014 in “Journal of Investigative Dermatology” This article reviews recent imaging and genetic tool advances that enable in vivo study of hair regeneration and assessment of skin parameters, but it reports no new clinical results.
25 citations
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February 2023 in “Aesthetic Surgery Journal” This review concludes that current clinical and preclinical evidence does not indicate oncologic safety concerns linked to photobiomodulation therapy for skin rejuvenation, including no clear evidence of increased cancer risk.
8 citations
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March 2014 in “Experimental Dermatology” Light and temperature affect the daily skin function rhythms in hairless rats, with temperature influencing water loss but not skin hydration.
5 citations
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October 2020 in “Veterinary record case reports” In this case report, a 15-year-old golden retriever with calcinosis cutis showed accelerated improvement in FLE-treated skin infections compared to untreated areas, highlighting FLE's potential as a treatment adjunct.
2 citations
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January 2022 in “BioMed Research International” This study found that using an LED array with an 863 nm wavelength delayed tumor development and reduced systemic inflammatory cytokines in DMBA/TPA-induced mouse skin tumors, suggesting potential but limited benefits of light therapy.
November 2022 in “Journal of Investigative Dermatology” This study found that using a home-use LED mask with specific wavelengths improved signs of skin aging in both ex-vivo and clinical settings.
2 citations
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March 2025 in “Archives of Dermatological Research” HEV light can harm or help skin and scalp, so safe exposure guidelines are needed.
January 2015 in “Journal of cosmetics, dermatological sciences and applications” This study observed that a low energy pulsed-light device combined with galvanic energy was effective and safe for reducing unwanted hair in individuals with dark skin types V and VI.
17 citations
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December 2015 in “International Journal of Cosmetic Science” This review discusses the effectiveness of non-thermal, non-ablative devices like light-emitting diodes in treating various skin and hair conditions but reports no new clinical findings.
10 citations
,
July 2022 in “Journal of Cosmetic Dermatology” This study suggests that Medicago sativa extract, combined with UVA light, may enhance pigmentation in hypopigmented skin and hair, offering potential treatment for vitiligo.
6 citations
,
July 2021 in “Microbial biotechnology” This study found that combining LED yellow light with an engineered strain expressing CXCL12 improved wound healing and reduced inflammation in a mouse model of scald wounds.
3 citations
,
October 1979 in “Laboratory animals” This study found that phenylbutazone and fluocinolone acetonide have similar anti-redness effects in both haired and hairless animals, making hairless rats a potential alternative for testing without needing depilation.
1 citations
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July 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses various topics from the 62nd Annual Montagna Symposium on the Biology of Skin, focusing on the diverse effects of light on skin biology, and reports no new clinical results.
19 citations
,
July 2009 in “Clinical and Experimental Dermatology” This article discusses how the balding scalp's exposure to UV and near-infrared light may accelerate aging, with changes detectable under ultraviolet light; it presents no new clinical findings.
October 2021 in “QJM: An International Journal of Medicine” This study found that four sessions of Intense Pulsed Light treatment significantly improved signs of photodamaged skin in adult female patients, as demonstrated by patient satisfaction and 3D camera assessments.
1 citations
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January 2009 in “Elsevier eBooks” This review discusses the mechanisms of laser and IPL hair removal, particularly for darker skin types, and reports no new findings, highlighting potential adverse effects like pigmentation changes or scarring with improper use.
64 citations
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June 2009 in “Photomedicine and Laser Surgery” This study found that monochromatic excimer light achieved complete remission in over 50% of plaque psoriasis cases and various levels of improvement in other skin conditions, including vitiligo and mycosis fungoides.
December 2025 in “Aesthetic Plastic Surgery” This study reported that the new near-infrared LED device showed significant improvements in skin rejuvenation and a slight increase in hair growth, with further research recommended for broader validation.
4 citations
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August 2015 in “Journal of Cosmetic Dermatology” This study found that UVA blocker-containing sunscreens instantly reduced follicular fluorescence due to porphyrins in facial skin, with the effect lasting for a few hours, influenced by sunscreen amount and formulation.
19 citations
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September 2011 in “Seminars in Cutaneous Medicine and Surgery” This review discusses home-use laser and light skin devices for various dermatological purposes and reports no new clinical findings; the authors highlight the need for dermatologists to evaluate these devices' clinical value.
6 citations
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June 2013 in “British Journal of Dermatology” This study found that intense pulsed light treatment primarily targets pigmented structures in hair follicles and may damage dermal papilla cells at high energy levels, but stem cells are mostly spared.
6 citations
,
May 2020 in “Nutrients” This review discusses the effects of calorie restriction on skin aging, highlighting its potential to benefit skin health by reducing age-related and photo-induced changes, although the impact of certain diets remains unexplored.
1 citations
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January 2021 in “Brazilian Journal of Medical and Biological Research” In this study, maternal exposure to constant light significantly altered the neonatal skin structure in rabbits, associated with reduced maternal melatonin levels.
19 citations
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February 2013 in “Journal of Investigative Dermatology” Touch domes in human skin are complex sensory structures not directly linked to hair.