Spatial Transcriptomics Reveals an Inflammatory Profile in Photoexposed Light Skin, Which Is Absent in Dark Skin

November 2025 in “ Journal of Investigative Dermatology ”

Michael Peake, B. Mambwe, Christopher M. O’Connor, Mike Bell, Mark D. Farrar, A.K. Langton

spatial transcriptomics photoexposed skin photoprotected skin inflammatory chemokines matrix metalloproteinases extracellular matrix immune cell activity photoageing melanin

Studysummary Light skin shows more inflammation from sun exposure than dark skin.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on jidonline.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin

November 2025 in “Journal of Investigative Dermatology”

Dark skin has stronger barriers and structure due to specific gene activity.

Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

research 837 Micro-regional transcriptome reveals local dermal-epidermal intercorrelation in atopic dermatitis

June 2020 in “Journal of Investigative Dermatology”

This study found that spatial transcriptomics can reveal hidden inflammation patterns in atopic dermatitis by correlating epidermal and dermal gene expression levels, improving understanding of skin pathology.

research 0041 Comparative multi-omics highlights inflammatory monocyte-derived dendritic cells as key mediators of UVB-induced photosensitivity

July 2025 in “Journal of Investigative Dermatology”

Monocyte-derived dendritic cells play a key role in UVB-induced skin sensitivity and inflammation.

Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes

August 2023 in “Journal of Investigative Dermatology”

This study using scRNA-seq on 96 skin biopsies from 51 healthy individuals revealed distinct cell signaling pathways in different skin sites, including unique pathways in facial and palmoplantar skin, which may explain their varying susceptibilities to skin disorders.