Micro-Regional Transcriptome Reveals Local Dermal-Epidermal Intercorrelation in Atopic Dermatitis

    June 2020 in “ Journal of Investigative Dermatology ”
    Takashi Miyai, Hiroshi Kawasaki, Masao Hosokawa, Hiroko Matsunaga, Ryosuke Satoh, Aiko Sekita, Haruko Takeyama, Masayuki Amagai, Haruhiko Koseki
    TLDR Atopic dermatitis shows a link between skin layers in inflammation, detectable with detailed gene analysis.
    The study investigated the spatial gene expression profiles in skin affected by atopic dermatitis (AD) using site-specific RNA-seq on 100 μm-diameter regions from wild-type and AD model mice. By analyzing 120 spots from 14 areas, researchers found that non-lesion areas showed weak inflammatory cytokine gene expression in the dermis, and similar areas in lesions exhibited differences in gene expression. This novel method revealed disease status not detectable by conventional analysis. Correlation analysis of dermis-epidermis pairs showed that certain epidermal genes correlated with dermal inflammatory cytokine levels, with some showing positive and others negative correlations. These findings were confirmed in human tissues, demonstrating dermal-epidermal intercorrelation in inflammation and highlighting the potential of micro-regional transcriptomics for understanding skin pathology.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 45 results

      community Topical melatonin/oral

      in Research/Science  12 upvotes 3 years ago
      The conversation discusses the potential positive effects of melatonin on hair growth. The original poster plans to try both oral and topical melatonin and is seeking recommendations for a good source.

      community Topical Dutasteride is Here.

      in Finasteride/Dutasteride  153 upvotes 3 years ago
      The availability of Topical Dutasteride, a potential treatment for hair loss, which can be purchased without prescription from MinoxidilMax. Other treatments discussed include Topical Finasteride and PRP injections, with discussion around dosage, efficacy, side-effects and safety.

      community Breaking hair loss news! GT20029 is a resounding success!

      in Product  138 upvotes 6 months ago
      GT20029, a new hair loss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.

      community A Different Take on Curing MBP

       16 upvotes 5 years ago
      Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

      community NootBro Recommendations… How Do We Feel

      in Research/Science  9 upvotes 5 months ago
      The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

    Similar Research

    5 / 1000+ results