Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals

    Ester Del Duca, Ana B. Pavel, Celina Dubin … Emma Guttman‐Yassky
    Studysummary This study observed significant differences in immune cell infiltration and gene expression across different skin sites, with the back displaying higher tolerance-promoting immune mechanisms, which may enhance epicutaneous immunotherapy outcomes.
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    Research cited in this study 3

    1. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin Cell host & microbe · 2017
    2. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    3. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012