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Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.

Higher levels of PD-L1 are linked to more severe hair loss in people with Alopecia Areata.

Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.

JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

Scientists found new nonsteroidal compounds that can act like natural male hormones and might help treat male fertility and hormone issues.

Targeting the Smoothened receptor shows promise for treating certain cancers.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

Hair follicles help attract immune cells to the skin during stress.

Pharmacophore models can predict liver toxicity and central nervous system toxicity, but they have limitations and specific requirements.

GDNF signaling helps in hair growth and skin healing after a wound.

Certain immune markers may predict chemotherapy response in mesothelioma, and nivolumab is a tolerable and effective treatment for advanced non-small cell lung cancer.

BMP4 helps stem cells turn into pigment-producing cells, affecting hair color and growth.

Vitamin D deficiency is linked to a higher chance of metabolic syndrome in women with PCOS.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Women with Polycystic Ovary Syndrome have higher levels of the hormone ghrelin, which may be linked to the cause of the condition.

The conclusion introduces a new way to classify skin cysts using their shape and genetic markers.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Vitamin D receptor may help protect against UV-induced skin cancer.

A new peptide, FOL-005, may help treat excessive hair growth by reducing a hair growth promoter, FGF7.

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.