Perifollicular Pink Halo: A Potential Dermoscopic Marker of Inflammation in Central Centrifugal Cicatricial Alopecia

November 2020 in “ Journal of The American Academy of Dermatology ”

Cheri Cunningham, Katherine G. Thompson, Andrea Murina

central centrifugal cicatricial alopecia perifollicular pink halo inflammation

TLDR Certain immune markers may predict chemotherapy response in mesothelioma, and nivolumab is a tolerable and effective treatment for advanced non-small cell lung cancer.

The document summarizes findings from two studies on cancer treatments. The first study with 54 patients (40 untreated and 14 pretreated) focused on immune cell diversity in mesothelioma, revealing that CD8+ TILs were predominant in the tumor stroma and that certain immune markers could predict chemotherapy response and prognosis, suggesting TIM-3 as a potential new treatment target. The second study involved 52 patients with advanced non-small cell lung cancer treated with nivolumab monotherapy, showing a 23% ORR, a median OS of 19.4 months, and a 41% 24-week PFS rate, confirming nivolumab's tolerability and durable efficacy. The document also references the BIRCH study on atezolizumab in advanced NSCLC but does not detail its results.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 88 upvotes 5 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 64 upvotes 11 months ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

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