Serum Level of Programmed Death Ligand 1 in Alopecia Areata Patients in Relation to Disease Severity

    May 2022 in “ Benha Journal of Applied Sciences ”
    Osama Alkady, Yasmin.M. Marei, Nora.M. El Sayed, Shymaa.M. Rezk
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    TLDR Higher levels of PD-L1 are linked to more severe hair loss in people with Alopecia Areata.
    The study "Serum Level of Programmed Death Ligand1 in Alopecia Areata Patients in Relation to Disease Severity" involved 60 patients with Alopecia Areata (AA) and 20 healthy volunteers. The researchers found that the levels of programmed death-ligand 1 (PD-L1), a protein that plays a crucial role in the immune system, were significantly different between the AA group and the control group. Furthermore, the severity of AA, as measured by the SALT score, was positively correlated with PD-L1 levels, indicating that PD-L1 could be an independent predictor of AA severity. This suggests that PD-L1 has a role in the development of AA and could potentially be used as an indicator of disease severity. The findings could also lead to the development of new treatment options for AA patients.
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