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This review discusses the impact of medical and surgical treatments for LUTS/BPH on ejaculatory function, highlighting that most treatments negatively affect it, except for some minimally invasive surgical therapies and specific medical therapies.

Finasteride can cause lasting erectile dysfunction, low libido, and depression in some patients.

This study observed that finasteride therapy reduced PSA levels by about 40% over a year in Chinese patients with benign prostatic hyperplasia, with varying effects based on baseline PSA levels.

This study found that finasteride improved urodynamic measures of obstruction in men with benign prostatic enlargement and lower urinary tract symptoms, with continued improvement over two years of treatment.

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

This study found that combination therapy with alpha-adrenergic blockers and 5α-reductase inhibitors significantly improved urinary symptoms, reduced prostate volume, and decreased the risk of acute urinary retention and postoperative surgery in patients with benign prostatic hyperplasia compared to monotherapy.

This study found that finasteride ethosome formulations with specific ethanol and soya lecithin concentrations significantly enhanced transdermal drug delivery compared to a potential nanogel.

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.

This study found that phosphodiesterase inhibitors may suppress the proliferation of benign prostatic hyperplasia epithelial cells by modulating CCL5 levels in low androgen conditions.

Finasteride reduces the need for prostate surgery but may increase the risk of depression and persistent sexual side effects.

This study found that Medicare patients with benign prostatic hyperplasia had high adherence to 5-alpha reductase inhibitor therapy, which was associated with a reduced risk of needing surgical intervention.

Finasteride interacts with terazosin, but not doxazosin; caution needed.

This study found an increased risk of intraoperative iris billowing in rabbits treated with finasteride, similar to those treated with tamsulosin, suggesting further research in humans is needed.

This study found that patients on dutasteride had $20.50 lower monthly medical costs compared to those on finasteride.

This study found that dual 5α-reductase inhibitors in rats decreased sperm quality and led to reduced pregnancy success, suggesting potential for use in male contraception.

This study concluded that men with benign prostatic hyperplasia receiving steroid 5α-reductase inhibitors, such as dutasteride or finasteride, have a higher risk of developing new onset type 2 diabetes compared to those taking tamsulosin.

This study successfully developed and validated a reverse-phase HPLC method for accurately determining finasteride and tamsulosin simultaneously in bulk and pharmaceutical formulations.

This review found that 5α-reductase inhibitors are associated with slightly increased rates of sexual dysfunction, gynecomastia, and mood disorders, but the true significance and persistence of these effects remain unclear.

This article is a commentary on another piece about the clinical efficacy of oral finasteride and reports no new results.

This study developed a precise and simple HPLC method for estimating tamsulosin and finasteride simultaneously in pharmaceutical forms, demonstrating good precision and potential usefulness for combined dosage analysis.

This review highlights that various commonly prescribed medications for chronic conditions may impact male fertility by affecting hormone secretion, sperm production, ejaculation, erectile function, and libido, although conclusive evidence is limited to specific drug groups.

This study suggests that finasteride may inhibit the enzyme phenylethanolamine N-methyltransferase, which could contribute to its sexual and psychological side effects.

This review examines recent advancements in analytical techniques used to quantify dutasteride, a medication for enlarged prostate, in various biological samples and its commercial forms, emphasizing methods such as HPTLC, GC-MS, and HPLC.

This investigation reports a new RP-HPLC method for accurately estimating Finasteride and Tamsulosin Hydrochloride in bulk and tablet forms, which may serve in routine pharmaceutical analysis.

This study found that testosterone and finasteride were significantly associated with reports of male-factor infertility based on FDA pharmacovigilance data from 2010 to 2020.