RP-HPLC Method for Simultaneous Estimation of Finasteride and Tamsulosin in Tablet Formulations

    January 2015 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Ashu Mittal, Shikha Parmar, Mohd. Aqil, Sadaf Jamal Gilani, Mohd. Aqil
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    TLDR A simple, precise method was created for estimating Tamsulosin and Finasteride in medicine using common lab solvents, showing good precision and stability.
    In 2014, researchers developed a simple, precise simultaneous High-Performance Liquid Chromatography (HPLC) method for estimating Tamsulosin (TAM) and Finasteride (FIN) in bulk and pharmaceutical dosage form. The method used easily available, inexpensive laboratory solvents and achieved separation on a spherisorb C-18 column with isocratic flow detected at 210nm. The mobile phase consisted of methanol: 0.03mM phosphate buffer pH 3.5 (70:30v/v) with a flow rate of 1.0mL/min. The method showed a linear response over a concentration range of 4-40μg/mL for tamsulosin and 10-80μg/mL for finasteride. The recovery of tamsulosin and finasteride was found to be in the range of 98.80-100.24% and 99.33-100.33%, respectively, indicating good precision and stability of the analytical method. The method was found to be selective for simultaneous estimation of tamsulosin and finasteride and could potentially be used for the estimation of these drugs in combined dosage form.
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