Finasteride Versus Dutasteride: A Real-World Economic Evaluation

February 2007 in “ PubMed ”

Thomas C Fenter, M. Chris Runken, Libby Black, Michael Eaddy

finasteride dutasteride 5-alpha reductase inhibitors benign prostatic hyperplasia Propecia Avodart 5ARIs BPH

TLDR Dutasteride is cheaper than finasteride for treating benign prostatic hyperplasia.

The study conducted a real-world economic evaluation comparing dutasteride and finasteride for treating benign prostatic hyperplasia in male patients over 50 years old. Using data from over 45 million patients, it was found that patients treated with dutasteride incurred $20.50 less per month in medical costs compared to those treated with finasteride. This cost reduction was primarily due to lower inpatient hospitalization charges for dutasteride patients. The study suggested that healthcare plans should consider these cost differences alongside pharmaceutical expenditures when evaluating these two 5-alpha reductase inhibitors (5ARIs).

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Research cited in this study

1 / 1 results

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations , December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

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6 / 1000+ results

community Hair Loss Drugs Ranked in Order of Efficacy

in Research/Science 67 upvotes 2 years ago

Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Sexual Dysfunction in Those with Androgenetic Alopecia on Dutasteride Versus Finasteride

in Finasteride/Dutasteride 113 upvotes 5 months ago

Dutasteride and finasteride have similar risks of sexual dysfunction for treating androgenetic alopecia. Users experience varying side effects, indicating individual differences in drug reactions.

community Update: 4 Month progress on Fin/Min plus dermaroller

in Progress Pictures 559 upvotes 1 year ago

A user shared a 4-month update on their hair regrowth progress using finasteride, minoxidil, a dermaroller, ketoconazole shampoo, multivitamins, and biotin, and received positive reactions and inquiries from others. They also mentioned lifestyle changes such as quitting creatine, alcohol, and smoking, which may have contributed to their success.

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 1 year ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community Dutasteride Infertility Debunked: Low T causes true infertility.

in Finasteride/Dutasteride 168 upvotes 8 months ago

Dutasteride and finasteride may temporarily affect semen quality but are unlikely to cause permanent infertility. The Kim et al. study is criticized for poor methodology, and many prefer hair retention over potential fertility concerns, using treatments like dutasteride, finasteride, and minoxidil.

Related Research

4 / 4 results

A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , January 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research Comparison of Clinical Efficacy of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors

1 citations , January 2012 in “Daehan namseong gwahag hoeji”

Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.