44 citations
,
May 2014 in “The American Surgeon” In this study, hair loss after laparoscopic sleeve gastrectomy was associated with zinc and iron levels, even within normal ranges, and a combined variable of zinc and iron predicted susceptibility to hair loss.
42 citations
,
July 1982 in “PubMed” This study found that a low estrogen-containing oral contraceptive normalized hormone levels and improved symptoms in women with polycystic ovary disease, with minimal side effects reported.
38 citations
,
January 2023 in “International Journal of Medical Sciences” This review discusses the potential of repeated low-level red-light therapy to inhibit myopia progression through metabolic effects, highlighting its molecular and cellular impact, but reports no new clinical results.
37 citations
,
March 2014 in “Journal of Trace Elements in Medicine and Biology” This study reported that Turkish males with male pattern androgenetic alopecia had significantly lower zinc and copper levels in their hair compared to healthy controls, suggesting these imbalances may play a role in the condition's etiology.
36 citations
,
October 2008 in “European journal of paediatric neurology” This study found that pediatric patients on valproic acid may experience hair loss due to reduced zinc and biotinidase levels within the first 3 months, with zinc depletion continuing to contribute by the 6th month.
35 citations
,
November 2019 in “Frontiers in Neuroendocrinology” This review discusses the sex differences in neuroactive steroid synthesis and their implications for nervous system functions and potential therapeutic approaches, but it provides no new experimental results.
35 citations
,
December 2009 in “Human reproduction” This study found that metformin treatment during pregnancy in women with PCOS was associated with higher SHBG levels in newborns, but did not affect androgen or estrogen levels at birth.
35 citations
,
January 2001 in “Journal of Animal Science” This study found that dietary selenium levels above 5 ppm can lead to selenosis in pigs, with white-haired pigs showing alopecia sooner than dark-haired pigs.
32 citations
,
January 1990 in “Clinical Endocrinology” This study found that women with female pattern androgenic alopecia have significantly higher levels of certain androgens and androgen sulfates compared to normal premenopausal women, suggesting markers for diagnosis and treatment efficacy.
30 citations
,
June 2009 in “British Journal of Dermatology” This study suggests that elevated aldosterone may contribute to androgenic alopecia development and its association with higher hypertension prevalence, emphasizing the importance of blood pressure screening in affected patients.
30 citations
,
January 2008 in “The Aging Male” This study found no difference in male pattern baldness between patients with benign prostate hyperplasia and prostate cancer, and no correlation with serum androgen levels.
29 citations
,
January 1998 in “Dermatology” This research reports that many acne patients have elevated androgen levels, contributing to a cycle that may lead to polycystic ovarian disease and potentially sterility.
29 citations
,
December 1989 in “The journal of nutrition/The Journal of nutrition” This study found that intestinal uptake of pantothenic acid in mice was not affected by dietary levels but may increase slightly in late-stage deficiency, though likely not significantly.
28 citations
,
September 2017 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome had significantly higher serum and intrafollicular levels of anti-Müllerian hormone compared to normovulatory women, indicating a potential marker for ovarian hyperstimulation syndrome risk.
28 citations
,
April 2017 in “Journal of cosmetic dermatology” This study found that while vitamin D deficiency is not the sole cause of alopecia areata, it may worsen the disease, suggesting supplementation could help in pediatric cases.
27 citations
,
March 2012 in “Dermatologic Surgery” This study found that finasteride treatment reduced caspase-1 expression, suggesting that androgens may influence immune processes in the hair cycle of androgenetic alopecia.
27 citations
,
October 2013 in “Experimental dermatology” In this study, hair shaft miR-29a levels were significantly lower in scleroderma patients than in controls, suggesting that hair microRNAs could serve as independent biomarkers for the disease.
27 citations
,
May 2002 in “The Journal of Clinical Endocrinology & Metabolism” This study found that brothers of women with PCOS exhibit elevated DHEAS levels, indicating a potential familial genetic trait, but did not show increased rates of premature balding.
26 citations
,
January 2020 in “Przegląd Menopauzalny” This review discusses the role of androgens in menopausal women's health, highlighting symptoms of both hyperandrogenemia and androgen deficiency, but reports no clinical results.
25 citations
,
October 1993 in “American Journal of Physical Anthropology” This study observed that in Namibian/Southern African men, hormone levels, particularly estradiol, influence the growth of body hair, with different effects noted in various ethnic groups.
24 citations
,
October 1994 in “Fertility and Sterility” This study suggests that in women with androgenic alopecia and men with premature balding, enhanced 5α-reductase activity and altered androgen conjugation, favoring sulfurylation, may be involved in scalp hair loss.
24 citations
,
May 2017 in “Journal of Cosmetic and Laser Therapy” This study reported that a new laser scanner using 655 nm red and 808 nm infrared lasers significantly improved hair density in patients with androgenic alopecia compared to both a laser hat and no treatment, without observable adverse effects.
24 citations
,
December 2012 in “Behavioural Brain Research” This study found that altering Allopregnanolone levels in neonatal rats affects their adult exploratory and anxiety-like behaviors and impairs avoidance learning.
24 citations
,
January 2012 in “Indian Journal of Dermatology, Venereology and Leprology” This study suggests that hypersensitivity and increased serum IgE levels might contribute to the pathogenesis of diffuse alopecia areata through intense local inflammatory infiltration.
23 citations
,
August 2017 in “Scientific Reports” Darker hair may lead to higher cortisol readings, suggesting a need to adjust for hair color in studies.
23 citations
,
January 2016 in “International Journal of Trichology” This study found that women with female pattern hair loss had significantly lower serum Vitamin D3 levels compared to healthy controls.
22 citations
,
January 2019 in “Climacteric” This study reports that oophorectomy significantly reduces serum testosterone levels in postmenopausal women, indicating the postmenopausal ovary's continued production of testosterone.
21 citations
,
January 2009 in “Indian journal of dermatology, venereology, and leprology” Vitamin B12, folate, ferritin, and iron levels are not linked to alopecia areata.
20 citations
,
January 2019 in “International journal of trichology” This study found that patients with alopecia areata had significantly lower Vitamin D levels compared to controls, with a negative correlation between Vitamin D levels and disease severity.
20 citations
,
December 1995 in “Journal of Chromatography B: Biomedical Sciences and Applications” Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.