Correlation Between Serum Granulysin Level and Clinical Activity in Patients with Alopecia Areata Before and After Tofacitinib Therapy

    August 2020 in “ Journal of Cosmetic Dermatology ”
    Muazzez Çiğdem Oba, Özge Aşkın, Özlem Balcı Ekmekçi, Server Serdaroğlu
    Studysummary This study found that in patients with alopecia areata, serum granulysin levels decreased significantly after treatment with tofacitinib and correlated with reduced disease severity, suggesting serum granulysin as an indicator of immunological activity and response to therapy.
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    Research cited in this study 10

    1. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    2. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    3. Treatment of an Alopecia Areata Patient with Tofacitinib Results in Regrowth of Hair and Changes in Serum and Skin Biomarkers Experimental Dermatology · 2016
    4. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    5. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    6. Serum Granulysin as a Possible Key Marker of the Activity of Alopecia Areata Journal of Dermatological Science · 2013
    7. Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions Journal of Dermatological Science · 2010
    8. Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone Archives of dermatological research · 2007
    9. Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study British Journal of Dermatology · 2004
    10. Role of Cytotoxic T Cells in Chronic Alopecia Areata Journal of Investigative Dermatology · 2000

    Related research 3

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    2. Resistant Alopecia Areata Treated with Tofacitinib International Journal of Trichology · 2022
    3. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018