January 2025 in “Nanotechnology Reviews” This study reported a green synthesis method for copper oxide nanoparticles using pumpkin seed extract, achieving significant antibacterial activity against Bacillus subtilis and moderate cytotoxic effects against certain cancer cell lines, indicating potential biomedical applications for these eco-friendly nanomaterials.
January 2024 in “Journal of applied biological chemistry” This study found that Glehnia littoralis and Andrographis paniculata may support hair growth by protecting against oxidative stress and increasing VEGF and Wnt/β-catenin signaling in human hair follicle dermal papilla cells, with enhanced effects when combined.
January 2026 in “E3S Web of Conferences” This study found that silver nanoparticles synthesized using Mitracarpus scaber extract showed potential hepatoprotective and anti-hyperplastic effects in rats, suggesting novel therapeutic strategies for managing liver injury and benign prostatic hyperplasia.
September 2019 in “Asian Journal of Pharmaceutical and Clinical Research” In this study, researchers found that the methanolic seed extract of Tectona grandis, known for its use in traditional medicine, demonstrated strong analgesic properties in Swiss albino mice, being effective at doses of 200–250 mg/kg and safe up to 1000 mg/kg.
April 2024 in “International journal of clinical trials” In this study, researchers found that a standardized extract of Sesbania grandiflora (SesZen-Bio™) improved hair density and thickness, as well as increased serum ferritin levels, over an 8-week period among participants, suggesting enhanced keratin production and follicle growth.
April 2024 in “Journal of pharmacy & pharmacognosy research” This study used in silico analysis to identify 4-[2-(4-nitrophenyl)ethylcarbamoyl]benzenesulfonyl as a potential inhibitor of the EGFR mutant associated with NSCLC, highlighting the need for further in vitro and in vivo validation.
26 citations
,
October 2017 in “Scientific reports” This study found that a bacterial endophyte from Zea nicaraguensis effectively targets and colonizes plant root hair cells, promoting growth and solubilizing insoluble phosphorus for nutrient uptake.
1 citations
,
January 2023 in “Journal of Pharmacognosy and Phytochemistry” This study provided detailed anatomical, physico-chemical, and chromatographic analyses to differentiate Dracaena trifasciata from potential adulterants in traditional medicine.
September 2025 in “International Journal of Environmental Sciences” This study explored the stem of Moullava spicata and found it to be rich in secondary metabolites and natural antioxidants, showing significant concentration-dependent antioxidant activity, which supports its ethnomedicinal use and provides a basis for further pharmacological research.
15 citations
,
June 2018 in “Journal of Chromatographic Science” This study successfully developed a method to measure four flavonoids from Platycladus orientalis leaves in rat plasma, which was used in a pharmacokinetic study on healthy rats.
4 citations
,
August 2023 in “Journal of Cosmetic Dermatology” Gynostemma pentaphyllum extract may help grow hair and prevent graying.
2 citations
,
January 2023 in “BioMed Research International” The researchers reported that a 5% Beta vulgaris L. extract nanogel showed better antialopecic activity in testosterone-induced alopecia in mice compared to a 2.5% concentration.
1 citations
,
January 2023 in “PubMed” In this study, Urtica dioica extract was found to significantly downregulate 5-alpha-reductase type II gene expression in skin cells, suggesting potential usefulness against androgenic skin diseases.
4 citations
,
October 2022 in “Evidence-based complementary and alternative medicine” This study found that Ficus carica extract enhanced fertility markers, including hormone levels and reproductive organ activity, in rats of both sexes, suggesting potential benefits for managing fertility issues.
3 citations
,
April 2018 in “JURNAL ILMU KEFARMASIAN INDONESIA” This study evaluated water extracts from Ambon banana humps incorporated into a cream bath and found it had suitable physical characteristics for use as a hair growth product.
1 citations
,
January 2016 in “Der pharmacia lettre” This study found that shampoo formulated with Eclipta alba extracts may promote hair growth and act as an antidandruff agent due to its antifungal activity against Malassezia.
This literature review suggests that Cyperus rotundus L extract is a promising natural agent for promoting hair growth due to its bioactive compounds and mechanisms of action, but emphasizes the need for further human clinical trials to confirm its safety and effectiveness.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This literature review suggests that Cyperus rotundus L extract shows promise as a natural hair growth agent due to its bioactive compounds and mechanisms that stimulate hair growth, although more human clinical trials are needed to confirm its safety and efficacy.
October 2025 in “INSOLOGI Jurnal Sains dan Teknologi” In this laboratory study on rabbits, the researchers observed that both FET and FHE fractions improved hair length and weight, but minoxidil still led to better results, highlighting the comparative effects of different treatments on hair growth over 28 days.
September 2017 in “Journal of Investigative Dermatology” In this study, the authors found that a botanical extract with anti-inflammatory and anti-oxidative properties stabilized hair loss and preserved natural hair pigmentation and strength over six months.
16 citations
,
January 1980 in “Planta Medica” This study found that alcoholic extracts of Cinchona succirubra, Dictamnus dasycarpus, Brassica juncea, and Sophora flavescens promoted hair growth in 5-week-old mice.
May 2026 in “Microorganisms” This study found that individuals with seborrheic alopecia had significant disruptions in their scalp microbiome, marked by imbalances in certain bacteria and fungi, and that a 12-week herbal shampoo intervention helped restore microbial diversity and improve clinical symptoms.
434 citations
,
October 2003 in “PTR. Phytotherapy research/Phytotherapy research” This review discusses the use of natural products in cosmetic preparations for skin and hair care, but reports no new research results.
111 citations
,
April 2023 in “Ultrasonics Sonochemistry” This review discusses the extraction, purification, and biological activities of maidenhairtree polysaccharides, emphasizing the higher efficiency of ultrasound-assisted extraction, but it reports no new clinical results.
81 citations
,
June 2010 in “Journal of Dermatological Treatment” This review discusses recent advancements in hair rejuvenation strategies and assesses the potential of herbal drugs as safer alternatives, but reports no new clinical results.
48 citations
,
May 2021 in “Molecules” The researchers found that plant extracts from Papaver rhoeas L., Clitoria ternatea L., and Carthamus tinctorius L. are effective natural cosmetic dyes, offering intense and stable colors without cytotoxicity.
47 citations
,
August 2016 in “Fitoterapia” This article reviews mechanisms by which herbal ingredients may stimulate or inhibit hair growth, and it reports no new clinical findings while suggesting potential for developing hair loss treatments.
41 citations
,
July 2015 in “Current Drug Discovery Technologies” This review discusses various plants and herbal formulations traditionally used for hair growth and notes their potential as safer alternatives to synthetic hair loss treatments, but reports no new clinical results.
25 citations
,
July 2017 in “Archives of Dermatological Research” This review summarizes preclinical and clinical information on herbal products for hair loss treatment, highlighting their mechanisms, follicular penetration, and potential side effects, suggesting they may offer alternatives to synthetic drugs with fewer side effects.
15 citations
,
April 2022 in “Biointerface Research in Applied Chemistry” This review presents current evidence on medicinal plants and their phytoconstituents, such as phenolic compounds, used in acne treatment, highlighting their potential as alternatives to conventional therapies due to issues like antibiotic resistance and high cost.