Analysis of Fractionation Potential from Ethanol Extract of Pacing Leaves (Costus spicatus (Jacq.) Sw.) as Raw Material for Herbal Medicine on Hair Growth Activity Test in Rabbits

October 2025 in “ INSOLOGI Jurnal Sains dan Teknologi ”

Sri Rezeki Samosir, Dina Maya Syari

Costus spicatus pacing leaf n-hexane fraction ethyl acetate fraction ethanol fraction minoxidil oxidative stress immunity hair growth Rogaine

TLDR Pacing leaf extracts can promote hair growth in rabbits, but minoxidil works better.

This study investigates the potential of pacing leaf fractionation for promoting hair growth in rabbits, focusing on oxidative stress and immunity as factors in hair loss. Using 5 male rabbits, the study applied different fractions—n-hexane (FHE), ethyl acetate (FEA), and ethanol (FET)—alongside minoxidil and a control. Over 28 days, FET and FHE showed promising results with average hair growth of 2.22 mm and 2.15 mm, respectively, and hair weight of 0.19 g for both, significantly affecting hair growth (p<0.05). However, minoxidil still outperformed the fractions in terms of hair growth and weight.

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