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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.

Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

Type-2 immunity may influence skin diseases and could be targeted for treatment.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.

The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.

COVID-19 protective measures led to skin irritation, hair loss, and brittle nails; using skin-friendly products and a healthy diet is recommended.

Immuno-cosmeceuticals from chicken egg yolk can effectively repair and improve damaged hair.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

The Leechbook shows how hair and sexual health were key to medieval masculinity and some remedies may still be useful.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

The document concludes that periocular hair disorders have various causes and treatments, and proper evaluation by specialists is important for management and prognosis.

Environmental factors can cause mutations in skin proteins, leading to skin disorders.

Hair restoration surgery has evolved over time, with a focus on natural-looking results and managing patient expectations, while also considering potential complications and the lifelong progression of male pattern baldness.

Adding amber particles to polyamide fibers makes them suitable for medical textiles like compression socks.

Adequate vitamin D might lower, and high hair chromium might increase DNA damage in obese women.

Grape seed proanthocyanidins can promote hair growth.

Wnt signaling is crucial for skin development and hair growth.

The ARTAS robotic system for hair restoration is efficient with fewer cuts than manual methods, but it's limited to certain hair types and can still leave scars.

The guide helps doctors diagnose hair problems by suggesting a thorough patient history, physical exams, and various diagnostic tools.

The document concludes that "Dictamnus" has a rich cultural history and potential as a herbal medicine, warranting more research into its effects and safety.

Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.

Long-term estrogen therapy in postmenopausal women can improve certain health markers, hair loss is common regardless of hormone use, stopping estrogen doesn't increase breast cancer risk, smoking does, and a balanced BMI is linked to lower mortality.

Skin aging reflects overall body aging and can indicate internal health conditions.

Skin grafting is a key procedure for repairing skin defects, with the success depending on the right graft choice, donor site management, and aftercare.

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.