September 2019 in “Journal of Investigative Dermatology” This study found that using human induced pluripotent stem cells (iPSC) carrying the causal mutation of Epidermolysis Bullosa simplex provides a robust model for understanding its molecular mechanisms and testing potential therapeutic targets.
9 citations
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April 2006 in “American Journal of Pathology” This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.
July 2025 in “Journal of Investigative Dermatology” TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.
92 citations
,
January 2012 in “International Journal of Biological Sciences” This article proposes an updated naming system for keratin-associated proteins and genes, aiming to improve data storage and retrieval by including species information and genetic variation.
August 2005 in “The Journal of Cell Biology” This abstract provides a graphic illustrating that mice lacking the Sgk3 gene exhibit thin coats and abnormal hair, suggesting a role for Sgk3 kinase in hair follicle growth, but reports no new experimental findings.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that skin organoids derived from iPSCs with an HS-associated NCSTN mutation showed defects in hair follicle stem cell differentiation and increased expression of inflammatory proteins related to hidradenitis suppurativa.
May 2023 in “ACS Biomaterials Science & Engineering” This study found that a silk fibroin/sodium alginate scaffold effectively delivers human umbilical mesenchymal stem cells to promote scarless wound healing and hair follicle regeneration in vivo by inducing specific cellular processes and mitigating endoplasmic reticulum stress.
3 citations
,
December 2014 in “Annals of Laboratory Medicine” In this study, a somatic KRAS mutation was identified in a Korean infant with nevus sebaceus and associated extracutaneous manifestations, suggesting a diagnosis of nevus sebaceus syndrome.
1 citations
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April 2017 in “Journal of Investigative Dermatology” This proof-of-concept study reported that a new, ultra-fast, one-step immunohistochemistry method improved the interpretation of Mohs surgery slides, particularly for poorly differentiated tumors.
June 1996 in “Journal of Dermatological Science”
9 citations
,
December 2022 in “Antibiotics” This study found that coconut seed extract may effectively treat scabies in rabbits by improving infection signs and causing high mite mortality, suggesting its potential as a cost-effective herbal alternative.
98 citations
,
June 2001 in “Journal of biological chemistry/The Journal of biological chemistry” This study identified a cluster of genes on chromosome 17 related to hair keratin-associated proteins, including 37 genes forming seven multigene families, localized in the hair shaft's upper cortex.
1 citations
,
April 2010 in “Digital WPI” This study found that CLK1 is necessary for epidermal differentiation but does not affect sebocyte differentiation in a telogen skin stem cell line.
November 2022 in “Journal of Investigative Dermatology” This study found that DermaCult™ Keratinocyte Expansion Medium allows for significantly extended growth of human epidermal keratinocytes while maintaining their differentiation potential.
November 2022 in “Journal of Investigative Dermatology” This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.
4 citations
,
September 2015 in “JAAD case reports” This article reviews the characteristics and inheritance patterns of keratosis follicularis spinulosa decalvans, but it does not present new clinical findings, noting the disease's complex and poorly understood pathogenesis.
May 2026 in “Journal of Health and Allied Sciences NU” This study concluded that human epidermal stem cells cultured in MEM-α and EpiLife media with growth factors show high proliferation potential and plasticity, suggesting potential use in skin regenerative medicine.
June 2020 in “Annals of the Rheumatic Diseases” This observational study concluded that anti-Ku antibodies do not specifically indicate any systemic autoimmune disease or associated clinical phenotype.
3 citations
,
November 2011 in “Small GTPases” This study identified hair follicle stem cells as a source of squamous cell carcinoma in an inducible mouse model and proposes targeting these for future cancer therapies.
4 citations
,
May 1998 in “PubMed” This study found that the Bsk phenotype in mice did not result from a recombination event between specific keratin genes, leaving the gene linked to this mutation unidentified.
25 citations
,
August 2020 in “Experimental eye research/Experimental Eye Research” This review discusses cornea-specific keratin expression patterns in human and mouse development and reports no new experimental results; it highlights the need for investigating keratin mutations' role in pathology.
2 citations
,
October 2023 in “JURNAL ILMU KEFARMASIAN INDONESIA” In this study, researchers formulated a nanosuspension of kenikir leaf extract that meets physical criteria and exhibits cytotoxic activity against MCF-7 breast cancer cells.
February 1996 in “International Journal of Dermatology” This article offers a summary of the Seoul International Dermatology Symposium held in May 1995, but reports no new clinical findings.
November 2024 in “Experimental Dermatology” In this pilot study, researchers isolated skin-derived precursor-like cells from human-induced pluripotent stem cell-derived skin organoids, revealing their potential for future hair regenerative applications by exhibiting self-renewal and key marker expression.
April 2023 in “Journal of Investigative Dermatology” In this study, the KPAI and KP-IGA scoring systems for assessing keratosis pilaris showed excellent interrater and intrarater reliability, offering standardized measures for clinical and research use.
53 citations
,
August 2005 in “The Journal of Cell Biology” This study found that the absence of Sgk3 in mice leads to impaired hair follicle maturation, characterized by reduced cell proliferation, increased apoptosis, and premature regression.
15 citations
,
November 2020 in “Development” This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.
24 citations
,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers identified two new keratin-associated proteins, hKAP1.6 and hKAP1.7, in human hair follicles, contributing to understanding hair fiber differentiation.
November 2025 in “Journal of Investigative Dermatology” KLHL24-mutant stem cells help understand skin and heart disease.
40 citations
,
June 2013 in “Scientific Reports” This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.