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    Glossary Keratinocyte Differentiation

    process where skin cells mature and produce protective keratin

    Keratinocyte differentiation, also known as keratinocyte maturation, is the process by which keratinocytes, the primary cells in the outer layer of the skin, develop and change as they move from the deeper layers to the surface. During this journey, they produce keratin, a protective protein, and eventually form the tough, outermost layer of the skin that acts as a barrier against environmental damage. This process is crucial for maintaining skin integrity and function.

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    1. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    2. Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin Experimental dermatology · 2002 · 96 citations
    3. p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network Journal of Biological Chemistry · 2011 · 82 citations
    4. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations
    5. Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22 PLOS Genetics · 2015 · 52 citations
    6. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    7. Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression Journal of Investigative Dermatology · 2005 · 37 citations
    8. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    9. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    10. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation Journal of Investigative Dermatology · 2016 · 24 citations
    11. Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing International Journal of Molecular Medicine · 2015 · 23 citations
    12. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    13. Expression of Neutrophil Gelatinase-Associated Lipocalin in Calcium-Induced Keratinocyte Differentiation Journal of Korean Medical Science · 2008 · 20 citations
    14. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    15. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations
    16. The role of cathepsin E in terminal differentiation of keratinocytes Biological Chemistry · 2011 · 15 citations
    17. Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor α Expression During Squamous Differentiation of Cultured Keratinocytes 2000 · 15 citations
    18. Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages Cells · 2024 · 7 citations
    19. Differential effects of Wnt5a on the proliferation, differentiation and inflammatory response of keratinocytes Molecular Medicine Reports · 2017 · 6 citations
    20. Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene <i>ID2</i>, by contact sensitizers in human bulge‐derived keratinocytes Journal of Biochemical and Molecular Toxicology · 2010 · 6 citations
    21. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    22. Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales Scientific reports · 2022 · 5 citations
    23. Nuclear Topology, Epigenetics, and Keratinocyte Differentiation Journal of Investigative Dermatology · 2013 · 2 citations
    24. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    25. The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin PLoS ONE · 2025
    26. 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth 2023
    27. 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles 2021
    28. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    29. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    30. Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation. The Journal of Cell Biology · 1994 · 104 citations